Genetics and genetic biomarkers in sporadic colorectal cancer
JM Carethers, BH Jung - Gastroenterology, 2015 - Elsevier
Sporadic colorectal cancer (CRC) is a somatic genetic disease in which pathogenesis is
influenced by the local colonic environment and the patient's genetic background …
influenced by the local colonic environment and the patient's genetic background …
[HTML][HTML] Drug repurposing in oncology: Compounds, pathways, phenotypes and computational approaches for colorectal cancer
The strategy of using existing drugs originally developed for one disease to treat other
indications has found success across medical fields. Such drug repurposing promises faster …
indications has found success across medical fields. Such drug repurposing promises faster …
Discovery of common and rare genetic risk variants for colorectal cancer
To further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-
genome sequencing of 1,439 cases and 720 controls, imputed discovered sequence …
genome sequencing of 1,439 cases and 720 controls, imputed discovered sequence …
Association between telomere length and risk of cancer and non-neoplastic diseases: a Mendelian randomization study
Importance The causal direction and magnitude of the association between telomere length
and incidence of cancer and non-neoplastic diseases is uncertain owing to the susceptibility …
and incidence of cancer and non-neoplastic diseases is uncertain owing to the susceptibility …
Determining risk of colorectal cancer and starting age of screening based on lifestyle, environmental, and genetic factors
Background & Aims Guidelines for initiating colorectal cancer (CRC) screening are based
on family history but do not consider lifestyle, environmental, or genetic risk factors. We …
on family history but do not consider lifestyle, environmental, or genetic risk factors. We …
Novel common genetic susceptibility loci for colorectal cancer
Background Previous genome-wide association studies (GWAS) have identified 42 loci (P<
5× 10− 8) associated with risk of colorectal cancer (CRC). Expanded consortium efforts …
5× 10− 8) associated with risk of colorectal cancer (CRC). Expanded consortium efforts …
Large-scale genome-wide association study of East Asians identifies loci associated with risk for colorectal cancer
Background & Aims Genome-wide association studies (GWASs) have associated
approximately 50 loci with risk of colorectal cancer (CRC)—nearly one third of these loci …
approximately 50 loci with risk of colorectal cancer (CRC)—nearly one third of these loci …
Biological role of unsaturated fatty acid desaturases in health and disease
A Czumaj, T Śledziński - Nutrients, 2020 - mdpi.com
Polyunsaturated fatty acids (PUFAs) are considered one of the most important components
of cells that influence normal development and function of many organisms, both eukaryotes …
of cells that influence normal development and function of many organisms, both eukaryotes …
FADS1-arachidonic acid axis enhances arachidonic acid metabolism by altering intestinal microecology in colorectal cancer
Colonocyte metabolism shapes the microbiome. Metabolites are the main mediators of
information exchange between intestine and microbial communities. Arachidonic acid (AA) …
information exchange between intestine and microbial communities. Arachidonic acid (AA) …
Risk stratification for early-onset colorectal cancer using a combination of genetic and environmental risk scores: an international multi-center study
Background The incidence of colorectal cancer (CRC) among individuals aged younger
than 50 years has been increasing. As screening guidelines lower the recommended age of …
than 50 years has been increasing. As screening guidelines lower the recommended age of …