Activated B cells participate in either extrafollicular (EF) or germinal center (GC) responses.
Canonical responses are composed of a short wave of plasmablasts (PBs) arising from EF …

Hel** B cells and antibody responses is a major function of CD4+ T cells. It has been 10
years since the publication of Bcl6 as the lineage-defining transcription factor for T follicular …

Humoral responses in coronavirus disease 2019 (COVID-19) are often of limited durability,
as seen with other human coronavirus epidemics. To address the underlying etiology, we …

Antibodies are key immune effectors that confer protection against pathogenic threats. The
nature and longevity of the antibody response to SARS-CoV-2 infection are not well defined …

The identification of CD4+ T cells localizing to B cell follicles has revolutionized the
knowledge of how humoral immunity is generated. Follicular helper T (TFH) cells support …

CD4+ follicular helper T (Tfh) cells play a vital role in providing help for B cells undergoing
selection and differentiation into activated antibody-secreting cells in mammalian germinal …

Immunity to malaria has been linked to the availability and function of helper CD4+ T cells,
cytotoxic CD8+ T cells and γδ T cells that can respond to both the asymptomatic liver stage …

Abstract Development of a malaria vaccine remains a critical priority to decrease clinical
disease and mortality and facilitate eradication. Accordingly, RTS, S, a protein-subunit …

Many aspects of SARS-CoV-2 have fully conformed with the principles established by
decades of viral immunology research, ultimately leading to the crowning achievement of …

Understanding which arms of the immune response are responsible for protection against
SARS-CoV-2 infection is key to predicting long-term immunity and to inform vaccine design …