Deep brain stimulation targets in epilepsy: systematic review and meta‐analysis of anterior and centromedian thalamic nuclei and hippocampus

A Vetkas, A Fomenko, J Germann, C Sarica… - …, 2022 - Wiley Online Library
Deep brain stimulation (DBS) is a neuromodulatory treatment used in patients with drug‐
resistant epilepsy (DRE). The primary goal of this systematic review and meta‐analysis is to …

Role of HMGB1/TLR4 and IL-1β/IL-1R1 signaling pathways in epilepsy

S Zhang, F Chen, F Zhai, S Liang - Frontiers in Neurology, 2022 - frontiersin.org
Epilepsy is a chronic disorder of the nervous system characterized by recurrent seizures.
Inflammation is one of the six major causes of epilepsy, and its role in the pathogenesis of …

Characteristics, surgical outcomes, and influential factors of epilepsy in Sturge-Weber syndrome

S Wang, J Pan, M Zhao, X Wang, C Zhang, T Li… - Brain, 2022 - academic.oup.com
Few studies have reported the clinical presentation, surgical treatment, outcomes and
influential factors for patients with epilepsy and Sturge-Weber syndrome. This large-scale …

Identifying the neural network for neuromodulation in epilepsy through connectomics and graphs

A Vetkas, J Germann, G Elias, A Loh… - Brain …, 2022 - academic.oup.com
Deep brain stimulation is a treatment option for patients with drug-resistant epilepsy. The
precise mechanism of neuromodulation in epilepsy is unknown, and biomarkers are needed …

Utilization, surgical populations, centers, coverages, regional balance, and their influential factors of deep brain stimulation for Parkinson's disease: a large-scale …

F Meng, W Hu, S Wang, J Tam, Y Gao… - … Journal of Surgery, 2023 - journals.lww.com
Background: Deep brain stimulation (DBS) is an emerging and effective therapy for
Parkinson's disease (PD). However, little is known about its utilization, surgical populations …

Closed-loop adaptive deep brain stimulation in Parkinson's disease: procedures to achieve it and future perspectives

S Wang, G Zhu, L Shi, C Zhang, B Wu… - Journal of …, 2023 - content.iospress.com
Parkinson's disease (PD) is a neurodegenerative disease with a heavy burden on patients,
families, and society. Deep brain stimulation (DBS) can improve the symptoms of PD …

Efficacy and safety of combined deep brain stimulation with capsulotomy for comorbid motor and psychiatric symptoms in Tourette's syndrome: Experience and …

S Wang, S Fan, Y Gan, Y Zhang, Y Gao, T Xue… - Asian Journal of …, 2024 - Elsevier
Objectives To evaluate the efficacy and safety of combined deep brain stimulation (DBS)
with capsulotomy for comorbid motor and psychiatric symptoms in patients with Tourette's …

Long‐term seizure outcome during continuous bipolar hippocampal deep brain stimulation in patients with temporal lobe epilepsy with or without mesial temporal …

A Cukiert, CM Cukiert, JA Burattini, PP Mariani - Epilepsia, 2021 - Wiley Online Library
Objective We present the findings related to seizure outcome during hippocampal deep
brain stimulation (Hip‐DBS) in patients with refractory temporal lobe epilepsy. Methods …

Efficacy and safety of deep brain stimulation in drug resistance epilepsy: A systematic review and meta-analysis

AR Bahadori, P Javadnia, A Davari, M Sheikhvatan… - Neurosurgical …, 2024 - Springer
In the context of drug-resistant epilepsy, deep brain stimulation (DBS) has received FDA
approval. However, there have been reports of potential adverse effects, such as depression …

The potential therapeutic role of the HMGB1-TLR pathway in epilepsy

S Wang, Y Guan, T Li - Current Drug Targets, 2021 - ingentaconnect.com
Epilepsy is one of the most common serious neurological disorders, affecting over 70 million
people worldwide. For the treatment of epilepsy, antiepileptic drugs (AEDs) and surgeries …