The roles and implications of RNA m6A modification in cancer
Abstract N 6-Methyladenosine (m6A), the most prevalent internal modification in eukaryotic
mRNA, has been extensively and increasingly studied over the past decade. Dysregulation …
mRNA, has been extensively and increasingly studied over the past decade. Dysregulation …
Epigenetic regulation in the tumor microenvironment: molecular mechanisms and therapeutic targets
J Yang, J Xu, W Wang, B Zhang, X Yu… - Signal transduction and …, 2023 - nature.com
Over decades, researchers have focused on the epigenetic control of DNA-templated
processes. Histone modification, DNA methylation, chromatin remodeling, RNA modification …
processes. Histone modification, DNA methylation, chromatin remodeling, RNA modification …
RNA modifications: importance in immune cell biology and related diseases
L Cui, R Ma, J Cai, C Guo, Z Chen, L Yao… - Signal transduction and …, 2022 - nature.com
RNA modifications have become hot topics recently. By influencing RNA processes,
including generation, transportation, function, and metabolization, they act as critical …
including generation, transportation, function, and metabolization, they act as critical …
Targeting the RNA m6A modification for cancer immunotherapy
Abstract N 6-methyladenosine (m6A) is the most abundant epigenetic modification of RNA,
and its dysregulation drives aberrant transcription and translation programs that promote …
and its dysregulation drives aberrant transcription and translation programs that promote …
RNA modification in the immune system
Characterization of RNA modifications has identified their distribution features and
molecular functions. Dynamic changes in RNA modification on various forms of RNA are …
molecular functions. Dynamic changes in RNA modification on various forms of RNA are …
Inhibition of ALKBH5 attenuates I/R-induced renal injury in male mice by promoting Ccl28 m6A modification and increasing Treg recruitment
J Chen, C Xu, K Yang, R Gao, Y Cao, L Liang… - Nature …, 2023 - nature.com
Ischemia reperfusion injury (IRI) is a common cause of acute kidney injury (AKI). The role of
N6-methyladenosine (m6A) modification in AKI remains unclear. Here, we characterize the …
N6-methyladenosine (m6A) modification in AKI remains unclear. Here, we characterize the …
Crosstalk among m6A RNA methylation, hypoxia and metabolic reprogramming in TME: from immunosuppressive microenvironment to clinical application
F Zhang, H Liu, M Duan, G Wang, Z Zhang… - Journal of hematology & …, 2022 - Springer
The tumor microenvironment (TME), which is regulated by intrinsic oncogenic mechanisms
and epigenetic modifications, has become a research hotspot in recent years. Characteristic …
and epigenetic modifications, has become a research hotspot in recent years. Characteristic …
RNA m6A demethylase ALKBH5 regulates the development of γδ T cells
γδ T cells are an abundant T cell population at the mucosa and are important in providing
immune surveillance as well as maintaining tissue homeostasis. However, despite γδ T …
immune surveillance as well as maintaining tissue homeostasis. However, despite γδ T …
The emerging role of m6A modification in regulating the immune system and autoimmune diseases
Y Wang, L Li, J Li, B Zhao, G Huang, X Li… - Frontiers in Cell and …, 2021 - frontiersin.org
Over the past several decades, RNA modifications have rapidly emerged as an
indispensable topic in epitranscriptomics. N6-methyladenosine (m6A), namely, methylation …
indispensable topic in epitranscriptomics. N6-methyladenosine (m6A), namely, methylation …
m6A demethylase ALKBH5 is required for antibacterial innate defense by intrinsic motivation of neutrophil migration
Neutrophil migration into the site of infection is necessary for antibacterial innate defense,
whereas impaired neutrophil migration may result in excessive inflammation and even …
whereas impaired neutrophil migration may result in excessive inflammation and even …