Chromosomal rearrangements involving the NTRK1, NTRK2, and NTRK3 genes (NTRK
genes), which encode the high-affinity nerve growth factor receptor (TRKA), brain-derived …

Salivary gland neoplasms are a morphologically heterogenous group of lesions that are
often diagnostically challenging. In recent years, considerable progress in salivary gland …

PURPOSE To provide evidence-based recommendations for practicing physicians and
other healthcare providers on the management of salivary gland malignancy. METHODS …

Salivary gland carcinomas (SGC) account for less than 5% of head and neck malignant
neoplasms, further subcategorized in over 20 histological subtypes. For the most part …

Rearranged during transfection (RET) receptor tyrosine kinase was first identified over thirty
years ago as a novel transforming gene. Since its discovery and subsequent pathway …

Recently, we discovered the recurrent genomic rearrangement [t (4; 9)(q13; q31)] enabling
upregulation of the transcription factor Nuclear Receptor Subfamily 4 Group A Member 3 …

High-grade transformation (HGT) or dedifferentiation has been described in a variety of
salivary gland carcinomas, including acinic cell carcinoma, secretory carcinoma, adenoid …

Background: Secretory carcinoma (SC), originally described as mammary analogue SC, is a
predominantly low-grade salivary gland neoplasm characterized by a recurrent t (12; …

Intraductal carcinoma (IC) is the new World Health Organization designation for tumors
previously called “low-grade cribriform cystadenocarcinoma” and “low-grade salivary duct …

Myoepithelial carcinoma of salivary glands is an underrecognized and challenging entity
with a broad morphologic spectrum, including an EWSR1-rearranged clear cell variant …