Transforming growth factor β (TGF-β) and related growth factors are secreted pleiotropic
factors that play critical roles in embryogenesis and adult tissue homeostasis by regulating …

Transforming growth factor β (TGF-β) family members signal via heterotetrameric complexes
of type I and type II dual specificity kinase receptors. The activation and stability of the …

Breast cancer (BC) is the most frequently occurring malignancy in women worldwide.
Despite the substantial advancement in understanding the molecular mechanisms and …

It has recently been shown that the upregulation of a pseudogene specific to a protein-
coding gene could function as a sponge to bind multiple potential targeting microRNAs …

Angiogenesis is essential for tumor growth and metastasis. Understanding the regulation of
tumor angiogenesis has become increasingly important. MicroRNAs (miRNAs) are small …

Long noncoding RNAs (lncRNAs) have been proved to play important roles in cellular
processes of cancer, including the development, proliferation, and migration of cancer cells …

Platinum-based drugs are the firstline of treatment for non-small cell lung cancer (NSCLC),
but resistance to these drugs is a major obstacle to effective chemotherapy. Our previous …

TP53 mutations occur in many different types of cancers that produce mutant p53 proteins.
The mutant p53 proteins have lost wild-type p53 activity and gained new functions that …

MicroRNAs (miRNAs) are a type of non-coding RNAs with about~ 22nt nucleotides.
Increasing evidences have shown that miRNAs play critical roles in many human diseases …

MicroRNAs are dysregulated in breast cancer. Heterogeneous Nuclear Ribonucleoprotein
A2/B1 (HNRNPA2/B1) is a reader of the N (6)-methyladenosine (m6A) mark in primary …