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[HTML][HTML] GNAQ and GNA11 Genes: A Comprehensive Review on Oncogenesis, Prognosis and Therapeutic Opportunities in Uveal Melanoma
P Silva-Rodríguez, D Fernández-Díaz, M Bande… - Cancers, 2022 - mdpi.com
Simple Summary The development of uveal melanoma is a multifactorial and multi-step
process, in which specific and recurrent mutations arise early. Among the recurrently …
process, in which specific and recurrent mutations arise early. Among the recurrently …
Ocular melanoma: an overview of the current status
P Jovanovic, M Mihajlovic… - … journal of clinical …, 2013 - pmc.ncbi.nlm.nih.gov
Ocular melanoma is the second most common type of melanoma after cutaneous and the
most common primary intraocular malignant tumor in adults. Large majority of ocular …
most common primary intraocular malignant tumor in adults. Large majority of ocular …
TERT Promoter Mutations in Familial and Sporadic Melanoma
Cutaneous melanoma occurs in both familial and sporadic forms. We investigated a
melanoma-prone family through linkage analysis and high-throughput sequencing and …
melanoma-prone family through linkage analysis and high-throughput sequencing and …
[HTML][HTML] Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry
Mutually exclusive activating mutations in the GNAQ and GNA11 oncogenes, encoding
heterotrimeric Gαq family members, have been identified in∼ 83% and∼ 6% of uveal and …
heterotrimeric Gαq family members, have been identified in∼ 83% and∼ 6% of uveal and …
Mutations in GNA11 in Uveal Melanoma
CD Van Raamsdonk, KG Griewank… - … England Journal of …, 2010 - Mass Medical Soc
Background Uveal melanoma is the most common intraocular cancer. There are no effective
therapies for metastatic disease. Mutations in GNAQ, the gene encoding an alpha subunit of …
therapies for metastatic disease. Mutations in GNAQ, the gene encoding an alpha subunit of …
[HTML][HTML] A platform of synthetic lethal gene interaction networks reveals that the GNAQ uveal melanoma oncogene controls the hippo pathway through FAK
Activating mutations in GNAQ/GNA11, encoding Gαq G proteins, are initiating oncogenic
events in uveal melanoma (UM). However, there are no effective therapies for UM. Using an …
events in uveal melanoma (UM). However, there are no effective therapies for UM. Using an …
Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi
BRAF and NRAS are common targets for somatic mutations in benign and malignant
neoplasms that arise from melanocytes situated in epithelial structures, and lead to …
neoplasms that arise from melanocytes situated in epithelial structures, and lead to …
[HTML][HTML] Oncogenic mutations in GNAQ occur early in uveal melanoma
MD Onken, LA Worley, MD Long, S Duan… - … & visual science, 2008 - arvojournals.org
purpose. Early/initiating oncogenic mutations have been identified for many cancers, but
such mutations remain unidentified in uveal melanoma (UM). An extensive search for such …
such mutations remain unidentified in uveal melanoma (UM). An extensive search for such …
Phase II, open-label, randomized trial of the MEK1/2 inhibitor selumetinib as monotherapy versus temozolomide in patients with advanced melanoma
JM Kirkwood, L Bastholt, C Robert… - Clinical Cancer …, 2012 - aacrjournals.org
Purpose: To compare the efficacy and tolerability of the mitogen-activated protein
(MAP)/extracellular signal-regulated (ERK) kinase (MEK) 1/2 inhibitor selumetinib versus …
(MAP)/extracellular signal-regulated (ERK) kinase (MEK) 1/2 inhibitor selumetinib versus …
Uveal melanoma
Uveal melanoma, which arises from melanocytes residing in the stroma, is the most common
primary intraocular tumor in adults. Up to 50% of patients with primary uveal melanoma will …
primary intraocular tumor in adults. Up to 50% of patients with primary uveal melanoma will …