Chronic liver inflammation leads to fibrosis and cirrhosis, which is the 12th leading cause of
death in the United States. Hepatocyte steatosis is a component of metabolic syndrome and …

The volume of liver transplant varies widely by country and there has been an important
growth in volume in emerging countries. Most liver transplant candidates are prioritized for …

Background & Aims: Iron overload may be carcinogenic. Patients with hereditary
hemochromatosis (HH) are reportedly at a 20–200-fold risk of intrahepatic cancer, but the …

Hereditary hemochromatosis (HH) is a common inherited iron overload disorder. The vast
majority of patients carry the missense Cys282Tyr mutation of the HFE gene. Hepcidin, the …

Iron overload is a common clinical problem. Originally described in the 1800s by a German
pathologist [1], hemochromatosis is the result of inappropriate iron absorption that can lead …

The term 'hemochromatosis' was first used by von Recklinghausen, a German pathologist in
the late 1800s [1]; he determined that the pigmentation seen in patients with advanced …

Background In Ireland, the homozygote frequency of the C282Y mutation in the HFE gene is
1/83. The biochemical expression of this mutation is high in haemochromatosis (HH) …

Background and aims: Although most cases of hereditary haemochromatosis are associated
with homozygosity for the C282Y mutation of the HFE gene, clinical penetrance varies and …

Gata4 is a member of the zinc finger GATA transcription factor family and is required for liver
development during the embryonic stage. Gata4 expression is repressed during NAFLD …

The different prevalences of iron overload syndromes between Caucasians and Asians may
be accounted for by the differences in genetic background. The major mutation of …