Stress has long been suggested to be an important correlate of uncontrolled drinking and
relapse. An important hormonal response system to stress—the hypothalamic–pituitary …

Abstract The United States is in the midst of an opioid addiction and overdose crisis
precipitated and exacerbated by use of prescription opioid medicines. The majority of opioid …

Importance With the current opioid crisis, it is important to improve understanding of the
biological mechanisms of opioid use disorder (OUD). Objectives To detect genetic risk …

Cumulative acute psychosocial stress is thought to promote the development of a range of
disorders which suggests that biomarkers for the physiological response may become …

Reactions to stress vary between individuals, and physiological and behavioral responses
tend to be associated in distinct suites of correlated traits, often termed stress-co** styles …

Objective To determine whether adding mindfulness‐based eating and stress management
practices to a diet‐exercise program improves weight loss and metabolic syndrome …

Addictive diseases, including addiction to heroin, prescription opioids, or cocaine, pose
massive personal and public health costs. Addictions are chronic relapsing diseases of the …

Recent findings in epigenetics shed new light on the regulation of gene expression in the
central nervous system (CNS) during stress. The most frequently studied epigenetic …

Intrathecal morphine, used widely for post-cesarean (CS) analgesia, exerts its effect mainly
through μ-opioid receptors. Studies have found that genetic variability at position 118 of the …

Blunted stress reactivity resulting from early exposure to stress during childhood and
adolescence may increase vulnerability to addiction. Early life adversity (ELA) affects brain …