[HTML][HTML] Regulation of the hypothalamic-pituitary-adrenocortical stress response
The hypothalamo-pituitary-adrenocortical (HPA axis) is required for stress adaptation.
Activation of the HPA axis causes secretion of glucocorticoids, which act on multiple organ …
Activation of the HPA axis causes secretion of glucocorticoids, which act on multiple organ …
Neurobiological interactions between stress and the endocannabinoid system
Stress affects a constellation of physiological systems in the body and evokes a rapid shift in
many neurobehavioral processes. A growing body of work indicates that the …
many neurobehavioral processes. A growing body of work indicates that the …
Addiction and stress: An allostatic view
Allostasis, or stability through change, has most often been linked with challenges to
homeostasis, in which repeated challenges or stressors produce sufficient allostatic load to …
homeostasis, in which repeated challenges or stressors produce sufficient allostatic load to …
Drug addiction: hyperkatifeia/negative reinforcement as a framework for medications development
Compulsive drug seeking that is associated with addiction is hypothesized to follow a
heuristic framework that involves three stages (binge/intoxication, withdrawal/negative affect …
heuristic framework that involves three stages (binge/intoxication, withdrawal/negative affect …
The organization of the stress system and its dysregulation in depressive illness
PW Gold - Molecular psychiatry, 2015 - nature.com
Stressors are imminent or perceived challenges to homeostasis. The stress response is an
innate, stereotypic, adaptive response to stressors that has evolved in the service of …
innate, stereotypic, adaptive response to stressors that has evolved in the service of …
[HTML][HTML] Stress-induced plasticity and functioning of ventral tegmental dopamine neurons
The ventral tegmental area dopamine (VTA-DA) mesolimbic circuit processes emotional,
motivational, and social reward associations together with their more demanding cognitive …
motivational, and social reward associations together with their more demanding cognitive …
Targeting human glucocorticoid receptors in fear learning: a multiscale integrated approach to study functional connectivity
Fear extinction is a phenomenon that involves a gradual reduction in conditioned fear
responses through repeated exposure to fear-inducing cues. Functional brain connectivity …
responses through repeated exposure to fear-inducing cues. Functional brain connectivity …
Phasic vs sustained fear in rats and humans: role of the extended amygdala in fear vs anxiety
M Davis, DL Walker, L Miles, C Grillon - Neuropsychopharmacology, 2010 - nature.com
Data will be reviewed using the acoustic startle reflex in rats and humans based on our
attempts to operationally define fear vs anxiety. Although the symptoms of fear and anxiety …
attempts to operationally define fear vs anxiety. Although the symptoms of fear and anxiety …
[HTML][HTML] Importance of the brain corticosteroid receptor balance in metaplasticity, cognitive performance and neuro-inflammation
Bruce McEwen's discovery of receptors for corticosterone in the rat hippocampus introduced
higher brain circuits in the neuroendocrinology of stress. Subsequently, these receptors …
higher brain circuits in the neuroendocrinology of stress. Subsequently, these receptors …
Psychobiological mechanisms of resilience and vulnerability: implications for successful adaptation to extreme stress
DS Charney - American journal of Psychiatry, 2004 - Am Psychiatric Assoc
OBJECTIVE: Most research on the effects of severe psychological stress has focused on
stress-related psychopathology. Here, the author develops psychobiological models of …
stress-related psychopathology. Here, the author develops psychobiological models of …