The complex dance of organelles during mitochondrial division
Mitochondria are dynamic organelles that undergo cycles of fission and fusion events
depending on cellular requirements. During mitochondrial division, the GTPase dynamin …
depending on cellular requirements. During mitochondrial division, the GTPase dynamin …
Engineering conditional protein-protein interactions for dynamic cellular control
Conditional protein-protein interactions enable dynamic regulation of cellular activity and
are an attractive approach to probe native protein interactions, improve metabolic …
are an attractive approach to probe native protein interactions, improve metabolic …
Chemically inducible split protein regulators for mammalian cells
E Rihtar, T Lebar, D Lainšček, K Kores… - Nature Chemical …, 2023 - nature.com
Chemically inducible systems represent valuable synthetic biology tools that enable the
external control of biological processes. However, their translation to therapeutic …
external control of biological processes. However, their translation to therapeutic …
A fluorogenic chemically induced dimerization technology for controlling, imaging and sensing protein proximity
S Bottone, O Joliot, ZV Cakil, L El Hajji… - Nature …, 2023 - nature.com
Molecular tools enabling the control and observation of the proximity of proteins are
essential for studying the functional role of physical distance between two proteins. Here we …
essential for studying the functional role of physical distance between two proteins. Here we …
GAS41 promotes H2A. Z deposition through recognition of the N terminus of histone H3 by the YEATS domain
M Kikuchi, S Takase, T Konuma… - Proceedings of the …, 2023 - National Acad Sciences
Glioma amplified sequence 41 (GAS41), which has the Yaf9, ENL, AF9, Taf14, and Sas5
(YEATS) domain that recognizes lysine acetylation (Kac), regulates gene expression as a …
(YEATS) domain that recognizes lysine acetylation (Kac), regulates gene expression as a …
Synthetic Gene Circuits for Regulation of Next‐Generation Cell‐Based Therapeutics
Arming human cells with synthetic gene circuits enables to expand their capacity to execute
superior sensing and response actions, offering tremendous potential for innovative cellular …
superior sensing and response actions, offering tremendous potential for innovative cellular …
Small molecule-inducible gene regulatory systems in mammalian cells: progress and design principles
Highlights•Inducible gene regulation has been a critical tool in interrogating biological
systems.•Small-molecule induction enables regulation at the DNA, RNA, and protein …
systems.•Small-molecule induction enables regulation at the DNA, RNA, and protein …
Integrated compact regulators of protein activity enable control of signaling pathways and genome-editing in vivo
Viral proteases and clinically safe inhibitors were employed to build integrated compact
regulators of protein activity (iCROP) for post-translational regulation of functional proteins …
regulators of protein activity (iCROP) for post-translational regulation of functional proteins …