Roles of oxidative stress in synaptic dysfunction and neuronal cell death in Alzheimer's disease
Alzheimer's disease (AD) is a brain disorder that progressively undermines memory and
thinking skills by affecting the hippocampus and entorhinal cortex. The main …
thinking skills by affecting the hippocampus and entorhinal cortex. The main …
Targeting the NRF2 pathway for disease modification in neurodegenerative diseases: Mechanisms and therapeutic implications
C Mayer, L Riera-Ponsati, S Kauppinen… - Frontiers in …, 2024 - frontiersin.org
Neurodegenerative diseases constitute a global health issue and a major economic burden.
They significantly impair both cognitive and motor functions, and their prevalence is …
They significantly impair both cognitive and motor functions, and their prevalence is …
Unravelling of molecular biomarkers in synaptic plasticity of Alzheimer's disease: Critical role of the restoration of neuronal circuits
Learning and memory storage are the fundamental activities of the brain. Aberrant
expression of synaptic molecular markers has been linked to memory impairment in AD …
expression of synaptic molecular markers has been linked to memory impairment in AD …
Evaluating the role of N-Acetyl-L-Tryptophan in the Aβ 1-42-induced neuroinflammation and cognitive decline in Alzheimer's disease
Abstract Alzheimer's disease (AD), a neurodegenerative condition previously known to affect
the older population, is also now seen in younger individuals. AD is often associated with …
the older population, is also now seen in younger individuals. AD is often associated with …
Natural antioxidants that act against Alzheimer's disease through modulation of the NRF2 pathway: a focus on their molecular mechanisms of action
Characterized by a complex pathophysiology that includes the intraneuronal formation of
neurofibrillary tangles and the extracellular deposition of β-amyloid plaques, Alzheimer's …
neurofibrillary tangles and the extracellular deposition of β-amyloid plaques, Alzheimer's …
Alzheimer's Disease: Status of Low‐Dimensional Nanotherapeutic Materials
D Huang, W Liao, J Li, T Chen, X Wang… - Advanced Functional …, 2024 - Wiley Online Library
Alzheimer's disease (AD) is a chronic progressive neurodegenerative disease that
constitutes the third most common cause of death among elderly individuals. AD patients …
constitutes the third most common cause of death among elderly individuals. AD patients …
The contribution of initial concussive forces and resulting acrolein surge to β-amyloid accumulation and functional alterations in neuronal networks using a TBI-on-a …
EA Rogers, T Beauclair, J Martinez, SJ Mufti, D Kim… - Lab on a Chip, 2023 - pubs.rsc.org
Trauma-induced Alzheimer's disease (AD) is rapidly emerging as a major consequence of
traumatic brain injuries (TBI), with devastating social and economic impacts. Unfortunately …
traumatic brain injuries (TBI), with devastating social and economic impacts. Unfortunately …
Characterizing Oxidative Stress induced by Aβ Oligomers and the Protective Role of Carnosine in Primary Mixed Glia Cultures
V Cardaci, L Di Pietro, MC Zupan, J Sibbitts… - Free Radical Biology …, 2025 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive
decline and memory loss. A critical aspect of AD pathology is represented by oxidative …
decline and memory loss. A critical aspect of AD pathology is represented by oxidative …
Unveiling Potential Neurotoxic Mechansisms: Pb-Induced Activation of CDK5-p25 Signaling Axis in Alzheimer's Disease Development, Emphasizing CDK5 Inhibition …
M Lokesh, LJM Bandaru, A Rajanna, JS Rao… - Molecular …, 2024 - Springer
Alzheimer's disease (AD) is a complex neurodegenerative disorder with an etiology
influenced by various genetic and environmental factors. Heavy metals, such as lead (Pb) …
influenced by various genetic and environmental factors. Heavy metals, such as lead (Pb) …
Therapeutic Potential of Ascorbic Acid in the Management of Alzheimer's Disease: An Update
Background: Ascorbic acid is a potent natural antioxidant that protects against oxidative
stress and performs various bodily functions. It is commonly found in fruits and vegetables …
stress and performs various bodily functions. It is commonly found in fruits and vegetables …