How pathogens drive genetic diversity: MHC, mechanisms and misunderstandings

LG Spurgin, DS Richardson - Proceedings of the …, 2010 - royalsocietypublishing.org
Major histocompatibility complex (MHC) genes have been put forward as a model for
studying how genetic diversity is maintained in wild populations. Pathogen-mediated …

Does reduced MHC diversity decrease viability of vertebrate populations?

J Radwan, A Biedrzycka, W Babik - Biological conservation, 2010 - Elsevier
Loss of genetic variation may render populations more vulnerable to pathogens due to
inbreeding depression and depletion of variation in genes responsible for immunity against …

Divergent selection on locally adapted major histocompatibility complex immune genes experimentally proven in the field

C Eizaguirre, TL Lenz, M Kalbe, M Milinski - Ecology letters, 2012 - Wiley Online Library
Although crucial for the understanding of adaptive evolution, genetically resolved examples
of local adaptation are rare. To maximize survival and reproduction in their local …

Effects of an MHC‐DRB genotype and allele number on the load of gut parasites in the bank vole Myodes glareolus

A Kloch, W Babik, A Bajer, E Siński… - Molecular …, 2010 - Wiley Online Library
The major histocompatibility complex (MHC) genes code for the proteins responsible for
pathogen recognition. The MHC class II DRB gene is multiplicated in the bank vole, Myodes …

Major histocompatibility complex polymorphism: dynamics and consequences of parasite‐mediated local adaptation in fishes

C Eizaguirre, TL Lenz - Journal of fish biology, 2010 - Wiley Online Library
Parasitism is a common form of life and represents a strong selective pressure for host
organisms. In response to this evolutionary pressure, vertebrates have developed …

The ecoimmunology of invasive species

TA White, SE Perkins - Functional Ecology, 2012 - Wiley Online Library
Invasive populations frequently harbour a reduced parasite community compared with their
native counterparts. The loss of regulating enemies may result in re‐allocation of resources …

Major histocompatibility complex heterozygote advantage and widespread bacterial infections in populations of Chinook salmon (Oncorhynchus tshawytscha)

ML Evans, BD Neff - Molecular ecology, 2009 - Wiley Online Library
Despite growing evidence for parasite‐mediated selection on the vertebrate major
histocompatibility complex (MHC), little is known about variation in the bacterial parasite …

Spatial and temporal patterns of neutral and adaptive genetic variation in the endangered African wild dog (Lycaon pictus)

CD Marsden, R Woodroffe, MGL Mills… - Molecular …, 2012 - Wiley Online Library
Deciphering patterns of genetic variation within a species is essential for understanding
population structure, local adaptation and differences in diversity between populations …

Selection maintains MHC diversity through a natural population bottleneck

MK Oliver, SB Piertney - Molecular Biology and Evolution, 2012 - academic.oup.com
A perceived consequence of a population bottleneck is the erosion of genetic diversity and
concomitant reduction in individual fitness and evolutionary potential. Although reduced …

The effect of balancing selection on population differentiation: a study with HLA genes

DYC Brandt, J César, J Goudet… - G3: Genes, Genomes …, 2018 - academic.oup.com
Balancing selection is defined as a class of selective regimes that maintain polymorphism
above what is expected under neutrality. Theory predicts that balancing selection reduces …