How pathogens drive genetic diversity: MHC, mechanisms and misunderstandings
Major histocompatibility complex (MHC) genes have been put forward as a model for
studying how genetic diversity is maintained in wild populations. Pathogen-mediated …
studying how genetic diversity is maintained in wild populations. Pathogen-mediated …
Does reduced MHC diversity decrease viability of vertebrate populations?
Loss of genetic variation may render populations more vulnerable to pathogens due to
inbreeding depression and depletion of variation in genes responsible for immunity against …
inbreeding depression and depletion of variation in genes responsible for immunity against …
Divergent selection on locally adapted major histocompatibility complex immune genes experimentally proven in the field
Although crucial for the understanding of adaptive evolution, genetically resolved examples
of local adaptation are rare. To maximize survival and reproduction in their local …
of local adaptation are rare. To maximize survival and reproduction in their local …
Effects of an MHC‐DRB genotype and allele number on the load of gut parasites in the bank vole Myodes glareolus
The major histocompatibility complex (MHC) genes code for the proteins responsible for
pathogen recognition. The MHC class II DRB gene is multiplicated in the bank vole, Myodes …
pathogen recognition. The MHC class II DRB gene is multiplicated in the bank vole, Myodes …
Major histocompatibility complex polymorphism: dynamics and consequences of parasite‐mediated local adaptation in fishes
Parasitism is a common form of life and represents a strong selective pressure for host
organisms. In response to this evolutionary pressure, vertebrates have developed …
organisms. In response to this evolutionary pressure, vertebrates have developed …
The ecoimmunology of invasive species
Invasive populations frequently harbour a reduced parasite community compared with their
native counterparts. The loss of regulating enemies may result in re‐allocation of resources …
native counterparts. The loss of regulating enemies may result in re‐allocation of resources …
Major histocompatibility complex heterozygote advantage and widespread bacterial infections in populations of Chinook salmon (Oncorhynchus tshawytscha)
Despite growing evidence for parasite‐mediated selection on the vertebrate major
histocompatibility complex (MHC), little is known about variation in the bacterial parasite …
histocompatibility complex (MHC), little is known about variation in the bacterial parasite …
Spatial and temporal patterns of neutral and adaptive genetic variation in the endangered African wild dog (Lycaon pictus)
Deciphering patterns of genetic variation within a species is essential for understanding
population structure, local adaptation and differences in diversity between populations …
population structure, local adaptation and differences in diversity between populations …
Selection maintains MHC diversity through a natural population bottleneck
A perceived consequence of a population bottleneck is the erosion of genetic diversity and
concomitant reduction in individual fitness and evolutionary potential. Although reduced …
concomitant reduction in individual fitness and evolutionary potential. Although reduced …
The effect of balancing selection on population differentiation: a study with HLA genes
Balancing selection is defined as a class of selective regimes that maintain polymorphism
above what is expected under neutrality. Theory predicts that balancing selection reduces …
above what is expected under neutrality. Theory predicts that balancing selection reduces …