A guide to chemokines and their receptors
CE Hughes, RJB Nibbs - The FEBS journal, 2018 - Wiley Online Library
The chemokines (or chemotactic cytokines) are a large family of small, secreted proteins that
signal through cell surface G protein‐coupled heptahelical chemokine receptors. They are …
signal through cell surface G protein‐coupled heptahelical chemokine receptors. They are …
Human dendritic cells: their heterogeneity and clinical application potential in cancer immunotherapy
Dendritic cells (DC) are professional antigen presenting cells, uniquely able to induce naïve
T cell activation and effector differentiation. They are, likewise, involved in the induction and …
T cell activation and effector differentiation. They are, likewise, involved in the induction and …
Cross-tissue immune cell analysis reveals tissue-specific features in humans
Despite their crucial role in health and disease, our knowledge of immune cells within
human tissues remains limited. We surveyed the immune compartment of 16 tissues from 12 …
human tissues remains limited. We surveyed the immune compartment of 16 tissues from 12 …
[HTML][HTML] Tissue-specific abundance of interferon-gamma drives regulatory T cells to restrain DC1-mediated priming of cytotoxic T cells against lung cancer
Local environmental factors influence CD8+ T cell priming in lymph nodes (LNs). Here, we
sought to understand how factors unique to the tumor-draining mediastinal LN (mLN) impact …
sought to understand how factors unique to the tumor-draining mediastinal LN (mLN) impact …
CCL2/CCR2 signaling in cancer pathogenesis
Chemokines are a family of small cytokines, which guide a variety of immune/inflammatory
cells to the site of tumor in tumorigenesis. A dysregulated expression of chemokines is …
cells to the site of tumor in tumorigenesis. A dysregulated expression of chemokines is …
The chemokine system in innate immunity
CL Sokol, AD Luster - Cold Spring Harbor perspectives …, 2015 - cshperspectives.cshlp.org
Chemokines are chemotactic cytokines that control the migration and positioning of immune
cells in tissues and are critical for the function of the innate immune system. Chemokines …
cells in tissues and are critical for the function of the innate immune system. Chemokines …
Chemokines and chemokine receptors: positioning cells for host defense and immunity
JW Griffith, CL Sokol, AD Luster - Annual review of immunology, 2014 - annualreviews.org
Chemokines are chemo tactic cyto kines that control the migratory patterns and positioning
of all immune cells. Although chemokines were initially appreciated as important mediators …
of all immune cells. Although chemokines were initially appreciated as important mediators …
Multimodal control of dendritic cell functions by nociceptors
It is known that interactions between nociceptors and dendritic cells (DCs) can modulate
immune responses in barrier tissues. However, our understanding of the underlying …
immune responses in barrier tissues. However, our understanding of the underlying …
The effect of short-chain fatty acids on human monocyte-derived dendritic cells
The gut microbiota is essential for human health and plays an important role in the
pathogenesis of several diseases. Short-chain fatty acids (SCFA), such as acetate, butyrate …
pathogenesis of several diseases. Short-chain fatty acids (SCFA), such as acetate, butyrate …
Induction of interleukin-10 producing dendritic cells as a tool to suppress allergen-specific T helper 2 responses
S Schülke - Frontiers in immunology, 2018 - frontiersin.org
Dendritic cells (DCs) are gatekeepers of the immune system that control induction and
polarization of primary, antigen-specific immune responses. Depending on their …
polarization of primary, antigen-specific immune responses. Depending on their …