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Psilocybin reduces heroin seeking behavior and modulates inflammatory gene expression in the nucleus accumbens and prefrontal cortex of male rats
G Floris, KR Dabrowski, MT Zanda, SE Daws - Molecular Psychiatry, 2024 - nature.com
Preclinical and human studies indicate psilocybin may reduce perseverant maladaptive
behaviors, including nicotine and alcohol seeking. Such studies in the opioid field are …
behaviors, including nicotine and alcohol seeking. Such studies in the opioid field are …
[HTML][HTML] A comprehensive analysis of fibromyalgia and the role of the endogenous opioid system
M García-Domínguez - Biomedicines, 2025 - mdpi.com
Fibromyalgia represents a chronic pain disorder characterized by musculoskeletal pain,
fatigue, and cognitive impairments. The exact mechanisms underlying fibromyalgia remain …
fatigue, and cognitive impairments. The exact mechanisms underlying fibromyalgia remain …
Neuroinflammatory history results in overlap** transcriptional signatures with heroin exposure in the nucleus accumbens and alters responsiveness to heroin in …
G Floris, MT Zanda, KR Dabrowski, SE Daws - Translational Psychiatry, 2024 - nature.com
Recent progress in psychiatric research has highlighted neuroinflammation in the
pathophysiology of opioid use disorder (OUD), suggesting that heightened immune …
pathophysiology of opioid use disorder (OUD), suggesting that heightened immune …
A single-nucleus transcriptomic atlas of medium spiny neurons in the rat nucleus accumbens
Neural processing of rewarding stimuli involves several distinct regions, including the
nucleus accumbens (NAc). The majority of NAc neurons are GABAergic projection neurons …
nucleus accumbens (NAc). The majority of NAc neurons are GABAergic projection neurons …
Single-nucleus RNA-sequencing of orbitofrontal cortex in rat model of methamphetamine-induced sensitization
Q Li, ZP Yu, YG Li, ZH Tang, YF Hu, MJ Wang… - Neuroscience …, 2024 - Elsevier
The behavioral sensitization, characterized by escalated behavioral responses triggered by
recurrent exposure to psychostimulants, involves neurobiological mechanisms that are brain …
recurrent exposure to psychostimulants, involves neurobiological mechanisms that are brain …
66. INTEGRATED SINGLE-CELL MULTIOMIC PROFILING OF CAUDATE NUCLEUS SUGGESTS KEY MECHANISMS IN ALCOHOL USE DISORDER
N Green, H Gao, X Chu, P McGuire, D Lai… - European …, 2024 - Elsevier
Background Alcohol use disorder (AUD) is a complex genetic disease that affects millions of
people worldwide. The caudate nucleus is a key brain region involved in reward processing …
people worldwide. The caudate nucleus is a key brain region involved in reward processing …
Machine learning analysis of the orbitofrontal cortex transcriptome of human opioid users identifies Shisa7 as a translational target relevant for heroin-seeking …
RJ Ellis, JMN Ferland, T Rahman, JL Landry… - Biological …, 2024 - Elsevier
Background Identifying neurobiological targets predictive of the molecular
neuropathophysiological signature of human opioid use disorder (OUD) could expedite new …
neuropathophysiological signature of human opioid use disorder (OUD) could expedite new …
[HTML][HTML] Sex-specific Concordance of Striatal Transcriptional Signatures of Opioid Addiction in Human and Rodent Brains
Opioid use disorder (OUD) has emerged as a severe, ongoing public health emergency.
Current, frontline addiction treatment strategies fail to produce lasting abstinence in most …
Current, frontline addiction treatment strategies fail to produce lasting abstinence in most …
Transcriptional impacts of substance use disorder and HIV on human ventral midbrain neurons and microglia
AM Wilson, MM Jacobs, TY Lambert, A Valada… - bioRxiv, 2025 - biorxiv.org
For people with HIV (PWH), substance use disorders (SUDs) are a prominent neurological
risk factor, and the impacts of both on dopaminergic pathways are a potential point of …
risk factor, and the impacts of both on dopaminergic pathways are a potential point of …
Accurate sample deconvolution of pooled snRNA-seq using sex-dependent gene expression patterns
GM Twa, RA Phillips III, NJ Robinson, JJ Day - bioRxiv, 2024 - biorxiv.org
Single nucleus RNA sequencing (snRNA-seq) technology offers unprecedented resolution
for studying cell type-specific gene expression patterns. However, snRNA-seq poses high …
for studying cell type-specific gene expression patterns. However, snRNA-seq poses high …