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RNA modification: mechanisms and therapeutic targets
L Qiu, Q **g, Y Li, J Han - Molecular biomedicine, 2023 - Springer
RNA modifications are dynamic and reversible chemical modifications on substrate RNA
that are regulated by specific modifying enzymes. They play important roles in the regulation …
that are regulated by specific modifying enzymes. They play important roles in the regulation …
Renal cell carcinoma
The treatment of renal cell carcinoma (RCC) has changed greatly over the past 15 years.
Progress in the surgical management of the primary tumor and increased understanding of …
Progress in the surgical management of the primary tumor and increased understanding of …
VHL, the story of a tumour suppressor gene
L Gossage, T Eisen, ER Maher - Nature Reviews Cancer, 2015 - nature.com
Abstract Since the Von Hippel–Lindau (VHL) disease tumour suppressor gene VHL was
identified in 1993 as the genetic basis for a rare disorder, it has proved to be of wide medical …
identified in 1993 as the genetic basis for a rare disorder, it has proved to be of wide medical …
Comprehensive Study of the Clinical Phenotype of Germline BAP1 Variant-Carrying Families Worldwide
Background The BRCA1-associated protein-1 (BAP1) tumor predisposition syndrome (BAP1-
TPDS) is a hereditary tumor syndrome caused by germline pathogenic variants in BAP1 …
TPDS) is a hereditary tumor syndrome caused by germline pathogenic variants in BAP1 …
Inhibitors of protein methyltransferases and demethylases
Post-translational modifications of histones by protein methyltransferases (PMTs) and
histone demethylases (KDMs) play an important role in the regulation of gene expression …
histone demethylases (KDMs) play an important role in the regulation of gene expression …
Hypoxia-driven effects in cancer: characterization, mechanisms, and therapeutic implications
Hypoxia, a common feature of solid tumors, greatly hinders the efficacy of conventional
cancer treatments such as chemo-, radio-, and immunotherapy. The depletion of oxygen in …
cancer treatments such as chemo-, radio-, and immunotherapy. The depletion of oxygen in …
Critical roles of non-histone protein lysine methylation in human tumorigenesis
Several protein lysine methyltransferases and demethylases have been identified to have
critical roles in histone modification. A large body of evidence has indicated that their …
critical roles in histone modification. A large body of evidence has indicated that their …
Genomic profiling in renal cell carcinoma
The treatment landscape of metastatic renal cell carcinoma (RCC) has been revolutionized
over the past two decades, bringing forth an era in which more than a dozen therapeutic …
over the past two decades, bringing forth an era in which more than a dozen therapeutic …
Molecular genetics of clear-cell renal cell carcinoma
J Brugarolas - Journal of clinical oncology, 2014 - ascopubs.org
Renal cell carcinoma of clear-cell type (ccRCC) is an enigmatic tumor type, characterized by
frequent inactivation of the VHL gene (infrequently mutated in other tumor types) …
frequent inactivation of the VHL gene (infrequently mutated in other tumor types) …
Comprehensive review of BAP1 tumor predisposition syndrome with report of two new cases
The BRCA1‐associated protein‐1 (BAP1) tumor predisposition syndrome (BAP1‐TPDS) is a
recently identified hereditary cancer syndrome. Germline mutations in this tumor suppressor …
recently identified hereditary cancer syndrome. Germline mutations in this tumor suppressor …