The prediction of protein three-dimensional structure from amino acid sequence has been a
grand challenge problem in computational biophysics for decades, owing to its intrinsic …

Analyzing the microbiome of diverse species and environments using next-generation
sequencing techniques has significantly enhanced our understanding on metabolic …

Deep-learning methods have revolutionized protein structure prediction and design but are
presently limited to protein-only systems. We describe RoseTTAFold All-Atom (RFAA), which …

CRISPR-Cas systems provide microbes with adaptive immunity to infectious nucleic acids
and are widely employed as genome editing tools. These tools use RNA-guided Cas …

Abstract The Integrated Microbial Genomes & Microbiomes system v. 5.0 (IMG/M: https://img.
jgi. doe. gov/m/) contains annotated datasets categorized into: archaea, bacteria, eukarya …

Background The study of microbiomes using whole-metagenome shotgun sequencing
enables the analysis of uncultivated microbial populations that may have important roles in …

The widespread application of next-generation sequencing technologies has revolutionized
microbiome research by enabling high-throughput profiling of the genetic contents of …

Abstract The Genomes OnLine Database (GOLD)(https://gold. jgi. doe. gov/) is a manually
curated, daily updated collection of genome projects and their metadata accumulated from …

Productivity of ruminant livestock depends on the rumen microbiota, which ferment
indigestible plant polysaccharides into nutrients used for growth. Understanding the …

Our current knowledge about nucleocytoplasmic large DNA viruses (NCLDVs) is largely
derived from viral isolates that are co-cultivated with protists and algae. Here we …