It has been argued that the historical nature of evolution makes it a highly path-dependent
process. Under this view, the outcome of evolutionary dynamics could have resulted in …

Cells are the building blocks of biological complexity. They are complex systems sustained
by the coordinated cooperative dynamics of several biochemical networks. Their replication …

It has been proposed that during the early steps in the origin of life, small droplets could
have formed via the segregation of molecules from complex mixtures by phase separation …

The recent development of RNA replicating protocells and capsules that enclose complex
biosynthetic cascade reactions are encouraging signs that we are gradually getting better at …

Living cells achieve precise control of shape and size through sophisticated biochemical
machinery. However, such precision is extremely challenging to emulate in artificial cellular …

Cells define the minimal building blocks of life. How cellular life emerged and evolved
implies to cross the boundary between living and nonliving matter. Here we explore this …

This paper is a theoretical attempt to gain insight into the problem of how self-assembling
vesicles (closed bilayer structures) could progressively turn into minimal self-producing and …

The evolution of life in our biosphere has been marked by several major innovations. Such
major complexity shifts include the origin of cells, genetic codes or multicellularity to the …

In previous works we have explored the dynamics of chemically reacting proto-cellular
systems, under different experimental conditions and kinetic parameters, by means of our …

The growth, form, and division of prebiotic vesicles, membraneous bags of fluid of varying
components and shapes is hypothesized to have served as the substrate for the origin of life …