Neurological disorders–disorders of the brain, spine and associated nerves–are a leading
contributor to global disease burden with a shockingly large associated economic cost …

Early-life inflammation increases the risk for depression in later life. Here, we demonstrate
how early-life inflammation causes adolescent depressive-like symptoms: by altering the …

The success of base editors for the study and treatment of genetic diseases depends on the
ability to deliver them in vivo to the relevant cell types. Delivery via adeno-associated viruses …

Current genome-editing systems generally rely on inducing DNA double-strand breaks
(DSBs). This may limit their utility in clinical therapies, as unwanted mutations caused by …

Genetically encoded voltage indicators (GEVIs) hold immense potential for monitoring
neuronal population activity. To date, best-in-class GEVIs rely on one-photon excitation …

The circadian clock protein BMAL1 modulates glial activation and amyloid-beta deposition
in mice. However, the effects of BMAL1 on other aspects of neurodegenerative pathology …

Delivery of mRNA-based therapeutics to the perinatal brain holds great potential in treating
congenital brain diseases. However, nonviral delivery platforms that facilitate nucleic acid …

Alpha-synuclein is a presynaptic protein that forms abnormal cytoplasmic aggregates in
Lewy body disorders. Although nuclear alpha-synuclein localization has been described, its …

Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by a mutation or
deletion of the maternally inherited UBE3A allele. In neurons, the paternally inherited …

The major genetic cause of frontotemporal dementia and amyotrophic lateral sclerosis is a
G4C2 repeat expansion in C9ORF72. Efforts to combat neurodegeneration associated with …