Applications of focused ultrasound in the brain: from thermoablation to drug delivery

Y Meng, K Hynynen, N Lipsman - Nature Reviews Neurology, 2021 - nature.com
Focused ultrasound (FUS) is a disruptive medical technology, and its implementation in the
clinic represents the culmination of decades of research. Lying at the convergence of …

Clinical intervention using focused ultrasound (FUS) stimulation of the brain in diverse neurological disorders

H Baek, D Lockwood, EJ Mason, E Obusez… - Frontiers in …, 2022 - frontiersin.org
Various surgical techniques and pharmaceutical treatments have been developed to
improve the current technologies of treating brain diseases. Focused ultrasound (FUS) is a …

The relevance of skull density ratio in selecting candidates for transcranial MR-guided focused ultrasound

A Boutet, D Gwun, R Gramer, M Ranjan… - Journal of …, 2019 - thejns.org
OBJECTIVE Transcranial MR-guided focused ultrasound (MRgFUS) is a minimally invasive
treatment for movement disorders. Considerable interpatient variability in skull transmission …

Impact of skull density ratio on efficacy and safety of magnetic resonance–guided focused ultrasound treatment of essential tremor

M D'Souza, KS Chen, J Rosenberg, WJ Elias… - Journal of …, 2019 - thejns.org
OBJECTIVE Skull density ratio (SDR) assesses the transparency of the skull to ultrasound.
Magnetic resonance–guided focused ultrasound (MRgFUS) thalamotomy in essential tremor …

Evaluating the safety profile of focused ultrasound and microbubble-mediated treatments to increase blood-brain barrier permeability

D McMahon, C Poon, K Hynynen - Expert opinion on drug delivery, 2019 - Taylor & Francis
Introduction: Treatment of several diseases of the brain are complicated by the presence of
the skull and the blood-brain barrier (BBB). Focused ultrasound (FUS) and microbubble …

Ultrafast three-dimensional microbubble imaging in vivo predicts tissue damage volume distributions during nonthermal brain ablation

RM Jones, D McMahon, K Hynynen - Theranostics, 2020 - pmc.ncbi.nlm.nih.gov
Transcranial magnetic resonance imaging (MRI)-guided focused ultrasound (FUS) thermal
ablation is under clinical investigation for non-invasive neurosurgery, though its use is …

Two-step aberration correction: application to transcranial histotripsy

N Lu, TL Hall, JR Sukovich, SW Choi… - Physics in Medicine …, 2022 - iopscience.iop.org
Objective: Phase aberration correction is essential in transcranial histotripsy to compensate
for focal distortion caused by the heterogeneity of the intact skull bone. This paper improves …

Molecular Modeling of Shockwave-Mediated Blood-Brain Barrier Opening for Targeted Drug Delivery

M Zhou, W Zhou, H Yang, L Cao, M Li… - … Applied Materials & …, 2024 - ACS Publications
Bubble-enhanced shock waves induce the transient opening of the blood-brain barrier
(BBB) providing unique advantages for targeted drug delivery of brain tumor therapy, but …

Accumulated thermal dose in MRI-guided focused ultrasound for essential tremor: repeated sonications with low focal temperatures

RM Jones, S Kamps, Y Huang, N Scantlebury… - Journal of …, 2019 - thejns.org
OBJECTIVE The object of this study was to correlate lesion size with accumulated thermal
dose (ATD) in transcranial MRI-guided focused ultrasound (MRgFUS) treatments of …

Echo‐focusing in transcranial focused ultrasound thalamotomy for essential tremor: A feasibility study

RM Jones, Y Huang, Y Meng, N Scantlebury… - Movement …, 2020 - Wiley Online Library
Background Transcranial magnetic resonance–guided focused ultrasound (TcMRgFUS)
systems currently employ computed tomography (CT)–based aberration corrections, which …