Dementia is a syndrome of global and progressive deterioration of cognitive skills,
especially memory, learning, abstract thinking, and orientation, usually affecting the elderly …

Dementia with Lewy bodies (DLB) is one of the most common degenerative dementias after
Alzheimer's disease (AD) dementia. DLB is under-diagnosed across populations but may be …

All forms of genetic variation originate from new mutations, making it crucial to understand
their rates and mechanisms. Here, we use long-read sequencing from Pacific Biosciences …

Lewy body (LB) pathology commonly occurs in individuals with Alzheimer's disease (AD)
pathology. However, it remains unclear which genetic risk factors underlie AD pathology, LB …

Tandem repeat (TR) catalogs are important components of repeat genoty** studies as
they define the genomic coordinates and expected motifs of all TR loci being analyzed. In …

The increasing development of sequence-based machine learning models has raised the
demand for manipulating sequences for this application. However, existing approaches to …

Parkinson's disease (PD) significantly impacts millions of individuals worldwide. Although
our understanding of the genetic foundations of PD has advanced, a substantial portion of …

Handgrip strength is a crucial indicator to monitor the change of cognitive function over time,
but its mechanism still needs to be further explored. We sampled 59 monozygotic twin pairs …

Dementia with Lewy bodies (DLB) is a common form of dementia in the elderly population.
We performed genome-wide DNA methylation map** of cerebellar tissue from …

Advances have led to a greater understanding of the genetics of Alzheimer's Disease (AD).
However, the gap between the predicted and observed genetic heritability estimates when …