Designing artificial metalloenzymes by tuning of the environment beyond the primary coordination sphere
Metalloenzymes catalyze a variety of reactions using a limited number of natural amino
acids and metallocofactors. Therefore, the environment beyond the primary coordination …
acids and metallocofactors. Therefore, the environment beyond the primary coordination …
Second sphere effects on oxygen reduction and peroxide activation by mononuclear iron porphyrins and related systems
Activation and reduction of O2 and H2O2 by synthetic and biosynthetic iron porphyrin
models have proved to be a versatile platform for evaluating second-sphere effects deemed …
models have proved to be a versatile platform for evaluating second-sphere effects deemed …
Synthetic Fe/Cu complexes: toward understanding heme-copper oxidase structure and function
Heme-copper oxidases (HCOs) are terminal enzymes on the mitochondrial or bacterial
respiratory electron transport chain, which utilize a unique heterobinuclear active site to …
respiratory electron transport chain, which utilize a unique heterobinuclear active site to …
Understanding and modulating metalloenzymes with unnatural amino acids, non-native metal ions, and non-native metallocofactors
Conspectus Metalloproteins set the gold standard for performing important functions,
including catalyzing demanding reactions under mild conditions. Designing artificial …
including catalyzing demanding reactions under mild conditions. Designing artificial …
Design and engineering of artificial oxygen-activating metalloenzymes
Many efforts are being made in the design and engineering of metalloenzymes with catalytic
properties fulfilling the needs of practical applications. Progress in this field has recently …
properties fulfilling the needs of practical applications. Progress in this field has recently …
Why copper is preferred over iron for oxygen activation and reduction in haem-copper oxidases
A Bhagi-Damodaran, MA Michael, Q Zhu, J Reed… - Nature …, 2017 - nature.com
Haem–copper oxidase (HCO) catalyses the natural reduction of oxygen to water using a
haem-copper centre. Despite decades of research on HCOs, the role of non-haem metal …
haem-copper centre. Despite decades of research on HCOs, the role of non-haem metal …
Molecular understanding of heteronuclear active sites in heme–copper oxidases, nitric oxide reductases, and sulfite reductases through biomimetic modelling
CJ Reed, QN Lam, EN Mirts, Y Lu - Chemical Society Reviews, 2021 - pubs.rsc.org
Heme–copper oxidases (HCO), nitric oxide reductases (NOR), and sulfite reductases (SiR)
catalyze the multi-electron and multi-proton reductions of O2, NO, and SO32−, respectively …
catalyze the multi-electron and multi-proton reductions of O2, NO, and SO32−, respectively …
[HTML][HTML] Transient β-hairpin formation in α-synuclein monomer revealed by coarse-grained molecular dynamics simulation
Parkinson's disease, originating from the intrinsically disordered peptide α-synuclein, is a
common neurodegenerative disorder that affects more than 5% of the population above age …
common neurodegenerative disorder that affects more than 5% of the population above age …
Engineering metalloprotein functions in designed and native scaffolds
Metalloproteins are crucial for life. The mutual relationship between metal ions and proteins
makes metalloproteins able to accomplish key processes in biological systems, often very …
makes metalloproteins able to accomplish key processes in biological systems, often very …
Systematic Tuning of Heme Redox Potentials and Its Effects on O2 Reduction Rates in a Designed Oxidase in Myoglobin
Cytochrome c Oxidase (C c O) is known to catalyze the reduction of O2 to H2O efficiently
with a much lower overpotential than most other O2 reduction catalysts. However, methods …
with a much lower overpotential than most other O2 reduction catalysts. However, methods …