Advances in technology have allowed for the sensitive, specific, and simultaneous
quantitative profiling of steroid precursors, bioactive steroids and inactive metabolites …

Steroidogenesis, the processes by which cholesterol is converted to steroid hormones,
involves transport proteins, enzymes, redox partners and cofactors. Most steroidogenic …

A great deal of information is known regarding the process of sex differentiation in fish, and
the mechanisms involved in primary sex determination are now beginning to be defined. A …

Background: Sugar-sweetened beverages are risk factors for type 2 diabetes; however, the
role of artificially sweetened beverages is unclear. Objective: The objective was to examine …

Over the past decade, it has become clear that the brain is a steroidogenic organ. The
steroids synthesized by the brain and nervous system, given the name neurosteroids, have …

Background: Cytochromes P450 catalyze the oxidation of a variety of hydrophobic
substrates. Sequence identities between P450 families are generally low (10–30%), and …

Continuous efforts have been devoted to unraveling the biophysiology and development of
the human fetal adrenal cortex, which is structurally and functionally unique from other …

Abstract Approximately 20–30% of PCOS women demonstrate excess adrenal precursor
androgen (APA) production, primarily using DHEAS as a marker of APA in general and more …

In the biosynthesis of steroid hormones, P450c17 is the single enzyme that catalyzes both
the 17α-hydroxylation of 21-carbon steroids and the 17, 20-lyase activity that cleaves the C …

Adrenarche is the puberty of the adrenal gland. The descriptive term pubarche indicates the
appearance of pubic hair, which may be accompanied by axillary hair. This process is …