METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer
Newly growing evidence highlights the essential role that epitranscriptomic marks play in the
development of many cancers; however, little is known about the role and implications of …
development of many cancers; however, little is known about the role and implications of …
RNA N6-methyladenosine (m6A) modification in HNSCC: molecular mechanism and therapeutic potential
X Sun, S Fu, X Yuan, X Pu, RK Wang, X Wang… - Cancer Gene …, 2023 - nature.com
Head and neck squamous cell carcinoma ranks seventh in incidence of malignant tumours
in the world. Although there are treatments including surgery, radiotherapy and …
in the world. Although there are treatments including surgery, radiotherapy and …
Targeting the “tumor microenvironment”: RNA-binding proteins in the spotlight in colorectal cancer therapy
Colorectal cancer (CRC) is the third most common cancer and has the second highest
mortality rate among cancers. The development of CRC involves both genetic and …
mortality rate among cancers. The development of CRC involves both genetic and …
Abrine, an IDO1 inhibitor, suppresses the immune escape and enhances the immunotherapy of anti-PD-1 antibody in hepatocellular carcinoma
X Liang, H Gao, J **ao, S Han, J He, R Yuan… - Frontiers in …, 2023 - frontiersin.org
Background Indoleamine-2, 3-dioxygenase 1 (IDO1) is responsible for tumor immune
escape by regulating T cell-associated immune responses and promoting the activation of …
escape by regulating T cell-associated immune responses and promoting the activation of …
N6-Methyladenosine-Related LncRNAs are potential remodeling indicators in the tumor microenvironment and prognostic markers in osteosarcoma
Z Wu, X Zhang, D Chen, Z Li, X Wu, J Wang… - Frontiers in …, 2022 - frontiersin.org
N6-Adenosine methylation, yielding N6-methyladenosine (m6A), is a reversible epigenetic
modification found in messenger RNAs and long non-coding RNAs (lncRNAs), which affects …
modification found in messenger RNAs and long non-coding RNAs (lncRNAs), which affects …
Crosstalk of eight types of RNA modification regulators defines tumor microenvironments, cancer hallmarks, and prognosis of lung adenocarcinoma
S Mao, Z Chen, Y Wu, H **ong, X Yuan - Journal of oncology, 2022 - Wiley Online Library
RNA modification has become an exciting underexplored field in recent years. In lung
adenocarcinoma (LUAD), m6A was the best characterized and most studied RNA …
adenocarcinoma (LUAD), m6A was the best characterized and most studied RNA …
N6‐methyladenosine promotes osteogenic differentiation of PDLSCs from periodontitis patients
X Zhang, J Liu, J Gao, W Sun, X Chen, X Wang… - Oral …, 2024 - Wiley Online Library
Objectives This study aimed to investigate the mechanism of N6‐methyladenosine (m6A) in
the osteogenic differentiation of periodontal ligament stem cells (PDLSCs) from periodontitis …
the osteogenic differentiation of periodontal ligament stem cells (PDLSCs) from periodontitis …
Manipulating the tumour immune microenvironment by N6-methyladenosine RNA modification
X Sun, H Wang, X Pu, Y Wu, X Yuan, X Wang… - Cancer Gene …, 2024 - nature.com
Abstract N6-methyladenosine (m6A), a posttranscriptional regulatory mechanism, is the
most common epigenetic modification in mammalian mRNA. M6A modifications play a …
most common epigenetic modification in mammalian mRNA. M6A modifications play a …
Characterization of m6A methylation modifications and tumor microenvironment infiltration in thyroid cancer
Background Thyroid cancer (TC) is the most common endocrine malignancy worldwide, and
immunotherapy is a new cancer treatment that stimulates and enhances the natural ability of …
immunotherapy is a new cancer treatment that stimulates and enhances the natural ability of …
[HTML][HTML] Integrating machine learning and bioinformatics analysis to m6A regulator-mediated methylation modification models for predicting glioblastoma patients' …
C Li, W Liu, C Liu, Q Luo, K Luo, C Wei, X Li… - Aging (Albany …, 2023 - ncbi.nlm.nih.gov
Background: Epigenetic regulations of immune responses are essential for cancer
development and growth. As a critical step, comprehensive and rigorous explorations of …
development and growth. As a critical step, comprehensive and rigorous explorations of …