METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer

R García-Vílchez, AM Añazco-Guenkova, S Dietmann… - Molecular cancer, 2023 - Springer
Newly growing evidence highlights the essential role that epitranscriptomic marks play in the
development of many cancers; however, little is known about the role and implications of …

RNA N6-methyladenosine (m6A) modification in HNSCC: molecular mechanism and therapeutic potential

X Sun, S Fu, X Yuan, X Pu, RK Wang, X Wang… - Cancer Gene …, 2023 - nature.com
Head and neck squamous cell carcinoma ranks seventh in incidence of malignant tumours
in the world. Although there are treatments including surgery, radiotherapy and …

Targeting the “tumor microenvironment”: RNA-binding proteins in the spotlight in colorectal cancer therapy

Y Zhang, Y Zhang, J Song, X Cheng, C Zhou… - International …, 2024 - Elsevier
Colorectal cancer (CRC) is the third most common cancer and has the second highest
mortality rate among cancers. The development of CRC involves both genetic and …

Abrine, an IDO1 inhibitor, suppresses the immune escape and enhances the immunotherapy of anti-PD-1 antibody in hepatocellular carcinoma

X Liang, H Gao, J **ao, S Han, J He, R Yuan… - Frontiers in …, 2023 - frontiersin.org
Background Indoleamine-2, 3-dioxygenase 1 (IDO1) is responsible for tumor immune
escape by regulating T cell-associated immune responses and promoting the activation of …

N6-Methyladenosine-Related LncRNAs are potential remodeling indicators in the tumor microenvironment and prognostic markers in osteosarcoma

Z Wu, X Zhang, D Chen, Z Li, X Wu, J Wang… - Frontiers in …, 2022 - frontiersin.org
N6-Adenosine methylation, yielding N6-methyladenosine (m6A), is a reversible epigenetic
modification found in messenger RNAs and long non-coding RNAs (lncRNAs), which affects …

Crosstalk of eight types of RNA modification regulators defines tumor microenvironments, cancer hallmarks, and prognosis of lung adenocarcinoma

S Mao, Z Chen, Y Wu, H **ong, X Yuan - Journal of oncology, 2022 - Wiley Online Library
RNA modification has become an exciting underexplored field in recent years. In lung
adenocarcinoma (LUAD), m6A was the best characterized and most studied RNA …

N6‐methyladenosine promotes osteogenic differentiation of PDLSCs from periodontitis patients

X Zhang, J Liu, J Gao, W Sun, X Chen, X Wang… - Oral …, 2024 - Wiley Online Library
Objectives This study aimed to investigate the mechanism of N6‐methyladenosine (m6A) in
the osteogenic differentiation of periodontal ligament stem cells (PDLSCs) from periodontitis …

Manipulating the tumour immune microenvironment by N6-methyladenosine RNA modification

X Sun, H Wang, X Pu, Y Wu, X Yuan, X Wang… - Cancer Gene …, 2024 - nature.com
Abstract N6-methyladenosine (m6A), a posttranscriptional regulatory mechanism, is the
most common epigenetic modification in mammalian mRNA. M6A modifications play a …

Characterization of m6A methylation modifications and tumor microenvironment infiltration in thyroid cancer

FH Ji, Z Yang, C Sun, S Lowe, XG Qiu - Clinical and Translational …, 2023 - Springer
Background Thyroid cancer (TC) is the most common endocrine malignancy worldwide, and
immunotherapy is a new cancer treatment that stimulates and enhances the natural ability of …

[HTML][HTML] Integrating machine learning and bioinformatics analysis to m6A regulator-mediated methylation modification models for predicting glioblastoma patients' …

C Li, W Liu, C Liu, Q Luo, K Luo, C Wei, X Li… - Aging (Albany …, 2023 - ncbi.nlm.nih.gov
Background: Epigenetic regulations of immune responses are essential for cancer
development and growth. As a critical step, comprehensive and rigorous explorations of …