Oligodendrocyte death and myelin loss in the cuprizone model: an updated overview of the intrinsic and extrinsic causes of cuprizone demyelination

M Zirngibl, P Assinck, A Sizov, AV Caprariello… - Molecular …, 2022 - Springer
Background The dietary consumption of cuprizone–a copper chelator–has long been known
to induce demyelination of specific brain structures and is widely used as model of multiple …

Thinking outside the box: non-canonical targets in multiple sclerosis

L Bierhansl, HP Hartung, O Aktas, T Ruck… - Nature reviews Drug …, 2022 - nature.com
Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system that
causes demyelination, axonal degeneration and astrogliosis, resulting in progressive …

The choroid plexus links innate immunity to CSF dysregulation in hydrocephalus

SM Robert, BC Reeves, E Kiziltug, PQ Duy, JK Karimy… - Cell, 2023 - cell.com
The choroid plexus (ChP) is the blood-cerebrospinal fluid (CSF) barrier and the primary
source of CSF. Acquired hydrocephalus, caused by brain infection or hemorrhage, lacks …

Connecting aging biology and inflammation in the omics era

KA Walker, N Basisty, DM Wilson, L Ferrucci - The Journal of Clinical …, 2022 - jci.org
Aging is characterized by the accumulation of damage to macromolecules and cell
architecture that triggers a proinflammatory state in blood and solid tissues, termed …

Positron Emission Tomography with [18F]‐DPA‐714 Unveils a Smoldering Component in Most Multiple Sclerosis Lesions which Drives Disease Progression

M Hamzaoui, J Garcia, G Boffa, A Lazzarotto… - Annals of …, 2023 - Wiley Online Library
Objective To determine the prognostic value of persisting neuroinflammation in multiple
sclerosis (MS) lesions, we developed a 18 kDa‐translocator‐protein‐positron emission …

Choroid plexus enlargement exacerbates white matter hyperintensity growth through glymphatic impairment

Y Li, Y Zhou, W Zhong, X Zhu, Y Chen… - Annals of …, 2023 - Wiley Online Library
Objective Choroid plexus (CP) is a key regulator in cerebrospinal fluid production, but its
contribution to glymphatic clearance function and association with white matter …

Choroid plexus volume in multiple sclerosis predicts expansion of chronic lesions and brain atrophy

S Klistorner, MH Barnett, J Parratt… - Annals of clinical …, 2022 - Wiley Online Library
Objectives Recent studies suggested that the expansion of long‐standing multiple sclerosis
(MS) lesions and an enlargement of choroid plexus may be linked to chronic inflammation …

[HTML][HTML] Choroid plexus enlargement is associated with neuroinflammation and reduction of blood brain barrier permeability in depression

N Althubaity, J Schubert, D Martins, T Yousaf… - NeuroImage: Clinical, 2022 - Elsevier
Background Recent studies have shown that choroid plexuses (CP) may be involved in the
neuro-immune axes, playing a role in the interaction between the central and peripheral …

Association of choroid plexus inflammation on MRI with clinical disability progression over 5 years in patients with multiple sclerosis

N Bergsland, MG Dwyer, D Jakimovski, E Tavazzi… - Neurology, 2023 - neurology.org
Background and Objectives Inflammation of the choroid plexus (CP) has been reported in
multiple sclerosis (MS). The AU1 association between CP inflammation and clinical …

Periventricular remyelination failure in multiple sclerosis: a substrate for neurodegeneration

M Tonietto, E Poirion, A Lazzarotto, V Ricigliano… - Brain, 2023 - academic.oup.com
In multiple sclerosis, spontaneous remyelination is generally incomplete and heterogeneous
across patients. A high heterogeneity in remyelination may also exist across lesions within …