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Oligodendrocyte death and myelin loss in the cuprizone model: an updated overview of the intrinsic and extrinsic causes of cuprizone demyelination
Background The dietary consumption of cuprizone–a copper chelator–has long been known
to induce demyelination of specific brain structures and is widely used as model of multiple …
to induce demyelination of specific brain structures and is widely used as model of multiple …
Thinking outside the box: non-canonical targets in multiple sclerosis
Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system that
causes demyelination, axonal degeneration and astrogliosis, resulting in progressive …
causes demyelination, axonal degeneration and astrogliosis, resulting in progressive …
The choroid plexus links innate immunity to CSF dysregulation in hydrocephalus
The choroid plexus (ChP) is the blood-cerebrospinal fluid (CSF) barrier and the primary
source of CSF. Acquired hydrocephalus, caused by brain infection or hemorrhage, lacks …
source of CSF. Acquired hydrocephalus, caused by brain infection or hemorrhage, lacks …
Connecting aging biology and inflammation in the omics era
Aging is characterized by the accumulation of damage to macromolecules and cell
architecture that triggers a proinflammatory state in blood and solid tissues, termed …
architecture that triggers a proinflammatory state in blood and solid tissues, termed …
Positron Emission Tomography with [18F]‐DPA‐714 Unveils a Smoldering Component in Most Multiple Sclerosis Lesions which Drives Disease Progression
Objective To determine the prognostic value of persisting neuroinflammation in multiple
sclerosis (MS) lesions, we developed a 18 kDa‐translocator‐protein‐positron emission …
sclerosis (MS) lesions, we developed a 18 kDa‐translocator‐protein‐positron emission …
Choroid plexus enlargement exacerbates white matter hyperintensity growth through glymphatic impairment
Y Li, Y Zhou, W Zhong, X Zhu, Y Chen… - Annals of …, 2023 - Wiley Online Library
Objective Choroid plexus (CP) is a key regulator in cerebrospinal fluid production, but its
contribution to glymphatic clearance function and association with white matter …
contribution to glymphatic clearance function and association with white matter …
Choroid plexus volume in multiple sclerosis predicts expansion of chronic lesions and brain atrophy
Objectives Recent studies suggested that the expansion of long‐standing multiple sclerosis
(MS) lesions and an enlargement of choroid plexus may be linked to chronic inflammation …
(MS) lesions and an enlargement of choroid plexus may be linked to chronic inflammation …
[HTML][HTML] Choroid plexus enlargement is associated with neuroinflammation and reduction of blood brain barrier permeability in depression
Background Recent studies have shown that choroid plexuses (CP) may be involved in the
neuro-immune axes, playing a role in the interaction between the central and peripheral …
neuro-immune axes, playing a role in the interaction between the central and peripheral …
Association of choroid plexus inflammation on MRI with clinical disability progression over 5 years in patients with multiple sclerosis
Background and Objectives Inflammation of the choroid plexus (CP) has been reported in
multiple sclerosis (MS). The AU1 association between CP inflammation and clinical …
multiple sclerosis (MS). The AU1 association between CP inflammation and clinical …
Periventricular remyelination failure in multiple sclerosis: a substrate for neurodegeneration
In multiple sclerosis, spontaneous remyelination is generally incomplete and heterogeneous
across patients. A high heterogeneity in remyelination may also exist across lesions within …
across patients. A high heterogeneity in remyelination may also exist across lesions within …