The broader sense of nonsense
The term 'nonsense-mediated mRNA decay'(NMD) was initially coined to describe the
translation-dependent degradation of mRNAs harboring premature termination codons …
translation-dependent degradation of mRNAs harboring premature termination codons …
Nonsense-mediated mRNA decay in neuronal physiology and neurodegeneration
The processes of mRNA export from the nucleus and subsequent mRNA translation in the
cytoplasm are of particular relevance in eukaryotic cells. In highly polarised cells such as …
cytoplasm are of particular relevance in eukaryotic cells. In highly polarised cells such as …
Residue-wise local quality estimation for protein models from cryo-EM maps
An increasing number of protein structures are being determined by cryogenic electron
microscopy (cryo-EM). Although the resolution of determined cryo-EM density maps is …
microscopy (cryo-EM). Although the resolution of determined cryo-EM density maps is …
New insights into no-go, non-stop and nonsense-mediated mRNA decay complexes
Highlights•Collided ribosomes form a unique disomal interface and are a hallmark of
slow/stalled translation.•Ribosome ubiquitination is triggered by ribosome collisions …
slow/stalled translation.•Ribosome ubiquitination is triggered by ribosome collisions …
[HTML][HTML] Genome-scale map** of DNA damage suppressors through phenotypic CRISPR-Cas9 screens
To maintain genome integrity, cells must accurately duplicate their genome and repair DNA
lesions when they occur. To uncover genes that suppress DNA damage in human cells, we …
lesions when they occur. To uncover genes that suppress DNA damage in human cells, we …
[HTML][HTML] Suppression of nonsense mutations by new emerging technologies
P Morais, H Adachi, YT Yu - International journal of molecular sciences, 2020 - mdpi.com
Nonsense mutations often result from single nucleotide substitutions that change a sense
codon (coding for an amino acid) to a nonsense or premature termination codon (PTC) …
codon (coding for an amino acid) to a nonsense or premature termination codon (PTC) …
Messenger RNA surveillance: current understanding, regulatory mechanisms, and future implications
Nonsense-mediated mRNA decay (NMD) is an evolutionarily conserved surveillance
mechanism in eukaryotes primarily deployed to ensure RNA quality control by eliminating …
mechanism in eukaryotes primarily deployed to ensure RNA quality control by eliminating …
The genetic architecture of phenotypic diversity in the Betta fish (Betta splendens)
The Betta fish displays a remarkable variety of phenotypes selected during domestication.
However, the genetic basis underlying these traits remains largely unexplored. Here, we …
However, the genetic basis underlying these traits remains largely unexplored. Here, we …
No-nonsense: insights into the functional interplay of nonsense-mediated mRNA decay factors
Nonsense-mediated messenger RNA decay (NMD) represents one of the main surveillance
pathways used by eukaryotic cells to control the quality and abundance of mRNAs and to …
pathways used by eukaryotic cells to control the quality and abundance of mRNAs and to …
[HTML][HTML] Protein model refinement for cryo-EM maps using AlphaFold2 and the DAQ score
As more protein structure models have been determined from cryogenic electron microscopy
(cryo-EM) density maps, establishing how to evaluate the model accuracy and how to …
(cryo-EM) density maps, establishing how to evaluate the model accuracy and how to …