Adipose tissue plays essential roles in maintaining lipid and glucose homeostasis. To date
several types of adipose tissue have been identified, namely white, brown, and beige, that …

Brown and beige adipocytes are mitochondria-enriched cells capable of dissipating energy
in the form of heat. These thermogenic fat cells were originally considered to function solely …

Aberrant scar formation, which includes keloid and hypertrophic scars, is associated with a
pathological disorganized wound healing process with chronic inflammation. The TGF …

The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) signaling
exert essential regulatory function in microbial-and onco-immunology through the induction …

Chronic low-grade inflammation plays a pivotal role in the pathogenesis of obesity, due to its
associated chronic diseases such as type II diabetes, cardiovascular diseases, pulmonary …

Mitochondria are fascinating structures of the cellular compartments that generate energy to
run the cells. However, inherent disorders of mitochondria due to diabetes can cause major …

The risk of chronic diseases caused by aging is reduced by caloric restriction (CR)-induced
immunometabolic adaptation. Here, we found that the matricellular protein, secreted protein …

Chronic overnutrition and obesity induces low-grade inflammation throughout the body.
Termed “meta-inflammation,” this chronic state of inflammation is mediated by macrophages …

Many of the comorbidities of obesity, including type 2 diabetes and cardiovascular diseases,
are related to the low‐grade chronic inflammation of white adipose tissue. Under white …

Background & Aims Transmembrane protein 173 (TMEM173 or STING) signaling by
macrophage activates the type I interferon-mediated innate immune response. The innate …