The maintenance and repair of many adult tissues are ensured by stem cells (SCs), which
reside at the top of the cellular hierarchy of these tissues. Functional assays, such as in vitro …

Chemoresistant metastatic relapse of minimal residual disease plays a significant role for
poor prognosis of cancer. Growing evidence supports a critical role of cancer stem cell …

Abstract Characterization of how the microenvironment, or niche, regulates stem cell activity
is central to understanding stem cell biology and to develo** strategies for the therapeutic …

Bone marrow transplantation is the primary therapy for numerous hematopoietic disorders.
The efficiency of bone marrow transplantation depends on the function of long-term …

Mutations in IDH1 and IDH2, the genes coding for isocitrate dehydrogenases 1 and 2, are
common in several human cancers, including leukemias, and result in overproduction of the …

Cancer stem cells (CSCs), also known as tumor‐initiating cells (TICs), are elucidated as
cells that can perpetuate themselves via autorestoration. These cells are highly resistant to …

Tissue engineering is a rapidly evolving discipline that seeks to repair, replace, or
regenerate specific tissues or organs by translating fundamental knowledge in physics …

Antiangiogenic therapy has been thought to hold significant potential for the treatment of
cancer. However, the efficacy of such treatments, especially in breast cancer patients, has …

We report here the isolation of a population of non-transformed pluripotent human cells from
bone marrow after a unique expansion/selection procedure. This procedure was designed …

The key hallmark of stem cells is their ability to self-renew while kee** a differentiation
potential. Intrinsic and extrinsic cell factors may contribute to a decline in these stem cell …