Generation of insulin-producing pancreatic β cells from multiple human stem cell lines
NJ Hogrebe, KG Maxwell, P Augsornworawat… - Nature protocols, 2021 - nature.com
We detail a six-stage planar differentiation methodology for generating human pluripotent
stem cell–derived pancreatic β cells (SC-β cells) that secrete high amounts of insulin in …
stem cell–derived pancreatic β cells (SC-β cells) that secrete high amounts of insulin in …
Engineering islets from stem cells for advanced therapies of diabetes
Diabetes mellitus is a metabolic disorder that affects more than 460 million people
worldwide. Type 1 diabetes (T1D) is caused by autoimmune destruction of β-cells, whereas …
worldwide. Type 1 diabetes (T1D) is caused by autoimmune destruction of β-cells, whereas …
[HTML][HTML] Deciphering early human pancreas development at the single-cell level
Understanding pancreas development can provide clues for better treatments of pancreatic
diseases. However, the molecular heterogeneity and developmental trajectory of the early …
diseases. However, the molecular heterogeneity and developmental trajectory of the early …
Parkinson-associated risk variant in distal enhancer of α-synuclein modulates target gene expression
F Soldner, Y Stelzer, CS Shivalila, BJ Abraham… - Nature, 2016 - nature.com
Genome-wide association studies (GWAS) have identified numerous genetic variants
associated with complex diseases, but mechanistic insights are impeded by a lack of …
associated with complex diseases, but mechanistic insights are impeded by a lack of …
Controlled induction of human pancreatic progenitors produces functional beta‐like cells in vitro
Directed differentiation of human pluripotent stem cells into functional insulin‐producing
beta‐like cells holds great promise for cell replacement therapy for patients suffering from …
beta‐like cells holds great promise for cell replacement therapy for patients suffering from …
Human pancreas development
A wealth of data and comprehensive reviews exist on pancreas development in mammals,
primarily mice, and other vertebrates. By contrast, human pancreatic development has been …
primarily mice, and other vertebrates. By contrast, human pancreatic development has been …
Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma
Tumors are largely classified by histologic appearance, yet morphologic features do not
necessarily predict cellular origin. To determine the origin of pancreatic ductal …
necessarily predict cellular origin. To determine the origin of pancreatic ductal …
Single-cell-resolved differentiation of human induced pluripotent stem cells into pancreatic duct-like organoids on a microwell chip
Creating in vitro models of diseases of the pancreatic ductal compartment requires a
comprehensive understanding of the developmental trajectories of pancreas-specific cell …
comprehensive understanding of the developmental trajectories of pancreas-specific cell …
Efficient generation of NKX6-1+ pancreatic progenitors from multiple human pluripotent stem cell lines
Human pluripotent stem cells (hPSCs) represent a renewable source of pancreatic beta
cells for both basic research and therapeutic applications. Given this outstanding potential …
cells for both basic research and therapeutic applications. Given this outstanding potential …
Pancreas organogenesis: from bud to plexus to gland
FC Pan, C Wright - Developmental dynamics, 2011 - Wiley Online Library
Pancreas oganogenesis comprises a coordinated and highly complex interplay of signaling
events and transcriptional networks that guide a step‐wise process of organ development …
events and transcriptional networks that guide a step‐wise process of organ development …