Oral solid dosage formulations and/or tablets have remained the preferred route of
administration by both patients and health care practitioners. Oral tablets are easy to …

Background Millions of patients are treated with opioid analgesics (OpAs) to relieve pain.
Unfortunately, these medications are subject to abuse and/or unintended misuse. Abuse …

Objective The reformulation of oxycodone hydrochloride controlled-release (CR) tablets in
August 2010 created a natural experiment at a national scale, providing an opportunity to …

The objective of the present study was to develop extended-release (ER) hot-melt extruded
(HME) abuse-deterrent pellets of acetaminophen, a model drug, by utilizing high molecular …

Drug self-administration procedures in laboratory settings allow us to closely model drug-
taking behavior in real-world settings. This review provides an overview of many of the …

Misuse of pharmaceuticals is of increasing drug policy and public health concern. A sco**
review was conducted on the diversionary use of pharmaceuticals for non‐medicinal use …

Objective: To prepare a polyethylene oxide-based tablet with high mechanical strength that
would release an opioid for once-or twice-daily administration. This tablet would also create …

Reformulated OxyContin®(oxycodone HCl controlled-release or ORF) was developed as a
tamper and abuse-deterrent product, to reduce the risk of product abuse, misuse and their …

The increased use of opioid pain medication has been mirrored by the increased misuse
and abuse of these drugs. As part of a multidisciplinary approach to this epidemic …

Throughout the world, industrialized nations look at the USA and are befuddled by its opioid
crisis. Between 1999 and 2011, we witnessed the number of opioid deaths in the USA …