Vibrational spectroscopic imaging of living systems: An emerging platform for biology and medicine

JX Cheng, XS ** structures with two-dimensional infrared spectroscopy
A Ghosh, JS Ostrander, MT Zanni - Chemical reviews, 2017 - ACS Publications
Proteins exhibit structural fluctuations over decades of time scales. From the picosecond
side chain motions to aggregates that form over the course of minutes, characterizing protein …

Live tissue intrinsic emission microscopy using multiphoton-excited native fluorescence and second harmonic generation

WR Zipfel, RM Williams, R Christie… - Proceedings of the …, 2003 - National Acad Sciences
Multicolor nonlinear microscopy of living tissue using two-and three-photon-excited intrinsic
fluorescence combined with second harmonic generation by supermolecular structures …

SERS microscopy as a tool for comprehensive biochemical characterization in complex samples

J Kneipp, S Seifert, F Gärber - Chemical Society Reviews, 2024 - pubs.rsc.org
Surface enhanced Raman scattering (SERS) spectra of biomaterials such as cells or tissues
can be used to obtain biochemical information from nanoscopic volumes in these …

Noninvasive morpho-molecular imaging reveals early therapy-induced senescence in human cancer cells

A Bresci, JH Kim, S Ghislanzoni, F Manetti, L Wu… - Science …, 2023 - science.org
Anticancer therapy screening in vitro identifies additional treatments and improves clinical
outcomes. Systematically, although most tested cells respond to cues with apoptosis, an …

Coherent anti-Stokes Raman scattering microscopy: chemical imaging for biology and medicine

CL Evans, XS **e - Annu. Rev. Anal. Chem., 2008 - annualreviews.org
Coherent anti-Stokes Raman scattering (CARS) microscopy is a label-free imaging
technique that is capable of real-time, nonperturbative examination of living cells and …

Coherent nonlinear optical imaging: beyond fluorescence microscopy

W Min, CW Freudiger, S Lu… - Annual review of physical …, 2011 - annualreviews.org
The quest for ultrahigh detection sensitivity with spectroscopic contrasts other than
fluorescence has led to various novel approaches to optical microscopy of biological …

Coherent anti-Stokes Raman scattering microscopy: instrumentation, theory, and applications

JX Cheng, XS **e - The Journal of Physical Chemistry B, 2004 - ACS Publications
Coherent anti-Stokes Raman scattering (CARS) microscopy permits vibrational imaging with
high-sensitivity, high speed, and three-dimensional spatial resolution. We review recent …

Interpreting second-harmonic generation images of collagen I fibrils

RM Williams, WR Zipfel, WW Webb - Biophysical journal, 2005 - cell.com
Fibrillar collagen, being highly noncentrosymmetric, possesses a tremendous nonlinear
susceptibility. As a result, second-harmonic generation (SHG) microscopy of collagen …

Nonlinear photonics using low‐dimensional metal‐halide perovskites: recent advances and future challenges

W Chen, F Zhang, C Wang, M Jia, X Zhao… - Advanced …, 2021 - Wiley Online Library
Low‐dimensional metal‐halide perovskites have exhibited significantly superior nonlinear
optical properties compared to traditional semiconductor counterparts, thanks to their …