Following pathogen infection or tissue damage, the stimulation of pattern recognition
receptors on the cell surface and in the cytoplasm of innate immune cells activates members …

NF-κB (nuclear factor kappa B) family transcription factors are master regulators of immune
and inflammatory processes in response to both injury and infection. In the latent state, NF …

The transcription factor NF-κB (nuclear factor kappa enhancer binding protein) controls
many processes, including immunity, inflammation and apoptosis. Ubiquitination regulates …

The activation of NF-κB and IKK requires an upstream kinase complex consisting of TAK1
and adaptor proteins such as TAB1, TAB2, or TAB3. TAK1 is in turn activated by TRAF6, a …

Osteoarthritis is one of the leading causes of pain and disability in the aged population due
to articular cartilage damage. This warrants investigation of signaling mechanisms that could …

Circulating tumour cells (CTCs) shed into blood from primary cancers include putative
precursors that initiate distal metastases. Although these cells are extraordinarily rare, they …

The CARD domain protein BCL10 and paracaspase MALT1 are essential for the activation
of IκB kinase (IKK) and NF-κB in response to T cell receptor (TCR) stimulation. Here we …

Background Innate immunity can facilitate early brain injury (EBI) following subarachnoid
hemorrhage (SAH). Numerous studies suggest that pyroptosis could exacerbate …

Nuclear factor kappa enhancer binding protein (NF-κB) regulates diverse biological
processes including immunity, inflammation, and apoptosis. A vast array of cellular stimuli …

The transcription factors nuclear factor-κB (NF-κB) and activating protein-1 (AP-1) are critical
regulators of stress responses, immunity, inflammation and cancer. A large variety of cellular …