Development of a vaccine against Staphylococcus aureus invasive infections: Evidence based on human immunity, genetics and bacterial evasion mechanisms

LS Miller, VG Fowler Jr, SK Shukla… - FEMS microbiology …, 2020 - academic.oup.com
Invasive Staphylococcus aureus infections are a leading cause of morbidity and mortality in
both hospital and community settings, especially with the widespread emergence of virulent …

Vaccination against bacterial infections: challenges, progress, and new approaches with a focus on intracellular bacteria

A Osterloh - Vaccines, 2022 - mdpi.com
Many bacterial infections are major health problems worldwide, and treatment of many of
these infectious diseases is becoming increasingly difficult due to the development of …

The immune evasion roles of Staphylococcus aureus protein A and impact on vaccine development

A Bear, T Locke, S Rowland-Jones… - Frontiers in Cellular …, 2023 - frontiersin.org
While Staphylococcus aureus (S. aureus) bacteria are part of the human commensal flora,
opportunistic invasion following breach of the epithelial layers can lead to a wide array of …

[HTML][HTML] Anti-virulence compounds against Staphylococcus aureus associated with bovine mastitis: A new therapeutic option?

YNV Sabino, PD Cotter, HC Mantovani - Microbiological Research, 2023 - Elsevier
Bovine mastitis represents a major economic burden faced by the dairy industry. S. aureus is
an important and prevalent bovine mastitis-associated pathogen in dairy farms worldwide …

Allergy—A New Role for T Cell Superantigens of Staphylococcus aureus?

G Abdurrahman, F Schmiedeke, C Bachert, BM Bröker… - Toxins, 2020 - mdpi.com
Staphylococcus aureus superantigens (SAgs) are among the most potent T cell mitogens
known. They stimulate large fractions of T cells by cross-linking their T cell receptor with …

IBT-V02: A Multicomponent Toxoid Vaccine Protects Against Primary and Secondary Skin Infections Caused by Staphylococcus aureus

H Karauzum, A Venkatasubramaniam… - Frontiers in …, 2021 - frontiersin.org
Staphylococcus aureus causes a wide range of diseases from skin infections to life
threatening invasive diseases such as bacteremia, endocarditis, pneumonia, surgical site …

rAAV expressing recombinant neutralizing antibody for the botulinum neurotoxin type a prophylaxis

AA Derkaev, EI Ryabova, IB Esmagambetov… - Frontiers in …, 2022 - frontiersin.org
Botulinum neurotoxin (BoNT) is one of the most dangerous bacterial toxins and a potential
biological weapon component. BoNT mechanism of pathological action is based on …

Evasion of Immunological Memory by S. aureus Infection: Implications for Vaccine Design

O Teymournejad, CP Montgomery - Frontiers in immunology, 2021 - frontiersin.org
Recurrent S. aureus infections are common, suggesting that natural immune responses are
not protective. All candidate vaccines tested thus far have failed to protect against S. aureus …

Recent advances in genomics-based approaches for the development of intracellular bacterial pathogen vaccines

MA Khan, A Amin, A Farid, A Ullah, A Waris, K Shinwari… - Pharmaceutics, 2022 - mdpi.com
Infectious diseases continue to be a leading cause of morbidity and mortality worldwide. The
majority of infectious diseases are caused by intracellular pathogenic bacteria (IPB) …

Dry and liquid formulations of IBT-V02, a novel multi-component toxoid vaccine, are effective against Staphylococcus aureus isolates from low-to-middle income …

Y Wang, I Mukherjee, A Venkatasubramaniam… - Frontiers in …, 2024 - frontiersin.org
Staphylococcus aureus is the leading cause of skin and soft tissue infections (SSTIs) in the
US as well as more serious invasive diseases, including bacteremia, sepsis, endocarditis …