Epigenetic modification plays a crucial regulatory role in the biological processes of
eukaryotic cells. The recent characterization of DNA and RNA methylation is still ongoing …

Methylcytosine (m5C) methylation is present in almost all types of RNA as an essential
epigenetic modification. It is dynamically modulated by its associated enzymes, including …

Transcription factors recognize specific genomic sequences to regulate complex gene-
expression programs. Although it is well-established that transcription factors bind to specific …

Although molecular dynamics (MD) simulations have been used extensively to study the
structural dynamics of proteins, the role of MD simulation in studies of nucleic acid based …

DNA G-quadruplexes are essential motifs in molecular biology performing a wide range of
functions enabled by their unique and diverse structures. In this study, we focus on the …

This review describes off-resonance R 1ρ relaxation dispersion NMR methods for
characterizing microsecond-to-millisecond chemical exchange in uniformly 13 C/15 N …

We developed a random forest machine learning (ML) model for the prediction of 1H and
13C NMR chemical shifts of nucleic acids. Our ML model is trained entirely on reproducing …

N 6-Methyladenosine (m6A) is an abundant epitranscriptomic modification that plays
important roles in many aspects of RNA metabolism. While m6A is thought to mainly function …

The majority of base pairs in double-stranded DNA exist in the canonical Watson-Crick
geometry. However, they can also adopt alternate Hoogsteen conformations in various …

In naked duplex DNA, G–C and A–T Watson-Crick base pairs exist in dynamic equilibrium
with their Hoogsteen counterparts. Here, we used nuclear magnetic resonance (NMR) …