Recent genomic studies have resulted in an emerging understanding of the role of
chromatin regulators in the development of cancer. EZH2, a histone methyl transferase …

During the course of malignant cancer progression, neoplastic cells undergo dynamic and
reversible transitions between multiple phenotypic states, the extremes of which are defined …

Since their identification in 1994, cancer stem cells (CSCs) have been objects of intensive
study. Their properties and mechanisms of formation have become a major focus of current …

Despite much recent progress, prostate cancer continues to represent a major cause of
cancer-related mortality and morbidity in men. Since early studies on the role of the …

Post-translational modification of histones provides an important regulatory platform for
processes such as gene transcription and DNA damage repair. It has become increasingly …

E-cadherin is a transmembrane glycoprotein which connects epithelial cells together at
adherens junctions. In normal cells, E-cadherin exerts its tumour suppressing role mainly by …

Adult T-cell leukemia/lymphoma (ATL) is an aggressive non-Hodgkin lymphoma with poor
prognosis and few treatment options for patients with relapsed, recurrent, or refractory …

Compelling evidence have demonstrated that bulk tumors can arise from a unique subset of
cells commonly termed “cancer stem cells” that has been proposed to be a strong driving …

Chromosomal rearrangements fusing the androgen-regulated gene TMPRSS2 to the
oncogenic ETS transcription factor ERG occur in approximately 50% of prostate cancers, but …

Enhancer of zeste homologue 2 (EZH2), the catalytic subunit of Polycomb repressive
complex 2 (PRC2), has attracted broad research attention in the past few years because of …