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Mechanisms of DNA damage, repair, and mutagenesis
Living organisms are continuously exposed to a myriad of DNA damaging agents that can
impact health and modulate disease‐states. However, robust DNA repair and damage …
impact health and modulate disease‐states. However, robust DNA repair and damage …
p53 mutations in human cancers
Mutations in the evolutionarily conserved codons of the p53 tumor suppressor gene are
common in diverse types of human cancer. The p53 mutational spectrum differs among …
common in diverse types of human cancer. The p53 mutational spectrum differs among …
The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer
We have identified a human homolog of the bacterial MutS and S. cerevisiae MSH proteins,
called hMSH2. Expression of hMSH2 in E. coli causes a dominant mutator phenotype …
called hMSH2. Expression of hMSH2 in E. coli causes a dominant mutator phenotype …
Inducible gene targeting in mice
A method of gene targeting that allows the inducible inactivation of a target gene in mice is
presented. The method uses an interferon-responsive promoter to control the expression of …
presented. The method uses an interferon-responsive promoter to control the expression of …
DNA glycosylases in the base excision repair of DNA
A wide range of cytotoxic and mutagenic DNA bases are removed by different DNA
glycosylases, which initiate the base excision repair pathway. DNA glycosylases cleave the …
glycosylases, which initiate the base excision repair pathway. DNA glycosylases cleave the …
Requirement of mammalian DNA polymerase-β in base-excision repair
Abstract SYNTHESIS of DNA by DNA polymerase-β is distributive on single-stranded DNA
templates, but short DNA gaps with a 5′ PO4 in the gap are filled processively to …
templates, but short DNA gaps with a 5′ PO4 in the gap are filled processively to …
Mechanisms of human DNA repair: an update
M Christmann, MT Tomicic, WP Roos, B Kaina - Toxicology, 2003 - Elsevier
The human genome, comprising three billion base pairs coding for 30000–40000 genes, is
constantly attacked by endogenous reactive metabolites, therapeutic drugs and a plethora of …
constantly attacked by endogenous reactive metabolites, therapeutic drugs and a plethora of …
Reconstitution of DNA base excision‐repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein.
Repair of a uracil‐guanine base pair in DNA has been reconstituted with the recombinant
human proteins uracil‐DNA glycosylase, apurinic/apyrimidinic endonuclease, DNA …
human proteins uracil‐DNA glycosylase, apurinic/apyrimidinic endonuclease, DNA …
Excision of deoxyribose phosphate residues by DNA polymerase β during DNA repair
Y Matsumoto, K Kim - Science, 1995 - science.org
Eukaryotic DNA polymerase β (pol β) can catalyze DNA synthesis during base excision DNA
repair. It is shown here that pol β also catalyzes release of 5′-terminal deoxyribose …
repair. It is shown here that pol β also catalyzes release of 5′-terminal deoxyribose …
DNA methylation and mutation
R Holliday, GW Grigg - Mutation Research/Fundamental and Molecular …, 1993 - Elsevier
Methylcytosine (5mC) in DNA is produced by post-synthetic modification of cytosine
residues, and it occurs primarily in CpG doublets in the mammalian genome. 5mC is a …
residues, and it occurs primarily in CpG doublets in the mammalian genome. 5mC is a …