p38 MAPK pathway in the heart: new insights in health and disease
R Romero-Becerra, AM Santamans… - International Journal of …, 2020 - mdpi.com
The p38 mitogen-activated kinase (MAPK) family controls cell adaptation to stress stimuli.
p38 function has been studied in depth in relation to cardiac development and function. The …
p38 function has been studied in depth in relation to cardiac development and function. The …
BCL2‑regulated apoptotic process in myocardial ischemia‑reperfusion injury
The leading cause of death in developed countries is cardiovascular disease, where
coronary heart disease is the main cause of death. Myocardial reperfusion is the most …
coronary heart disease is the main cause of death. Myocardial reperfusion is the most …
Vericiguat alleviates ventricular remodeling and arrhythmias in mouse models of myocardial infarction via CaMKII signaling
T Chen, B Kong, W Shuai, Y Gong, J Zhang, H Huang - Life Sciences, 2023 - Elsevier
Aims Maladaptive ventricular remodeling is a major cause of ventricular arrhythmias
following myocardial infarction (MI) and adversely impacts the quality of life of affected …
following myocardial infarction (MI) and adversely impacts the quality of life of affected …
Multi-omics analysis reveals phenylalanine enhance mitochondrial function and hypoxic endurance via LKB1/AMPK activation
Y Wu, Y Ma, Q Li, J Li, D Zhang, Y Zhang, Y Li… - Journal of Translational …, 2024 - Springer
Many studies have focused on the effects of small molecules, such as amino acids, on
metabolism under hypoxia. Recent findings have indicated that phenylalanine levels were …
metabolism under hypoxia. Recent findings have indicated that phenylalanine levels were …
ANP and BNP exert anti-inflammatory action via NPR-1/cGMP axis by interfering with canonical, non-canonical, and alternative routes of inflammasome activation in …
L Mezzasoma, VN Talesa, R Romani… - International Journal of …, 2020 - mdpi.com
Dysregulated inflammasome activation and interleukin (IL)-1β production are associated
with several inflammatory disorders. Three different routes can lead to inflammasome …
with several inflammatory disorders. Three different routes can lead to inflammasome …
CORM-3 ameliorates neurodegeneration in the amygdala and improves depression-and anxiety-like behavior in a rat model of combined traumatic brain injury and …
Y Li, LM Zhang, DX Zhang, WC Zheng, Y Bai… - Neurochemistry …, 2020 - Elsevier
Objective Emotional disturbances characterized by depression and anxiety among survivors
of traumatic brain injury (TBI) impact the quality of life severely. Currently, there is a lack of …
of traumatic brain injury (TBI) impact the quality of life severely. Currently, there is a lack of …
[HTML][HTML] The role of serine/threonine protein kinases in cardiovascular disease and potential therapeutic methods
Y Wu, Y Zou, C Song, K Cao, K Cai, S Chen… - Biomedicine & …, 2024 - Elsevier
Protein phosphorylation is an important link in a variety of signaling pathways, and most of
the important life processes in cells involve protein phosphorylation. Based on the amino …
the important life processes in cells involve protein phosphorylation. Based on the amino …
Advances in the Protective Mechanism of NO, H2S, and H2 in Myocardial Ischemic Injury
W Wang, T Ge, X Chen, Y Mao, Y Zhu - Frontiers in Cardiovascular …, 2020 - frontiersin.org
Myocardial ischemic injury is among the top 10 leading causes of death from cardiovascular
diseases worldwide. Myocardial ischemia is caused mainly by coronary artery occlusion or …
diseases worldwide. Myocardial ischemia is caused mainly by coronary artery occlusion or …
Downregulation of miR-214 promotes dilated Cardiomyopathy Progression through PDE5A-Mediated cGMP regulation
J Yan, X Wang, P Cao, Q Li, H Wu - Scientific Reports, 2024 - nature.com
Dilated cardiomyopathy (DCM) is a myocardial disorder resulting in a substantial decline in
cardiac function and potentially leading to heart failure. This research combines …
cardiac function and potentially leading to heart failure. This research combines …
[HTML][HTML] Xanthine derivative KMUP-1 ameliorates retinopathy
JL Yeh, CH Kuo, PW Shih, JH Hsu, I Peng… - Biomedicine & …, 2023 - Elsevier
Retinal neovascularization (RNV) and cell apoptosis observed in retinopathy are the most
common cause of vision loss worldwide. Increasing vascular endothelial growth factor …
common cause of vision loss worldwide. Increasing vascular endothelial growth factor …