p38 MAPK pathway in the heart: new insights in health and disease

R Romero-Becerra, AM Santamans… - International Journal of …, 2020 - mdpi.com
The p38 mitogen-activated kinase (MAPK) family controls cell adaptation to stress stimuli.
p38 function has been studied in depth in relation to cardiac development and function. The …

BCL2‑regulated apoptotic process in myocardial ischemia‑reperfusion injury

AY Korshunova, ML Blagonravov… - International …, 2021 - spandidos-publications.com
The leading cause of death in developed countries is cardiovascular disease, where
coronary heart disease is the main cause of death. Myocardial reperfusion is the most …

Vericiguat alleviates ventricular remodeling and arrhythmias in mouse models of myocardial infarction via CaMKII signaling

T Chen, B Kong, W Shuai, Y Gong, J Zhang, H Huang - Life Sciences, 2023 - Elsevier
Aims Maladaptive ventricular remodeling is a major cause of ventricular arrhythmias
following myocardial infarction (MI) and adversely impacts the quality of life of affected …

Multi-omics analysis reveals phenylalanine enhance mitochondrial function and hypoxic endurance via LKB1/AMPK activation

Y Wu, Y Ma, Q Li, J Li, D Zhang, Y Zhang, Y Li… - Journal of Translational …, 2024 - Springer
Many studies have focused on the effects of small molecules, such as amino acids, on
metabolism under hypoxia. Recent findings have indicated that phenylalanine levels were …

ANP and BNP exert anti-inflammatory action via NPR-1/cGMP axis by interfering with canonical, non-canonical, and alternative routes of inflammasome activation in …

L Mezzasoma, VN Talesa, R Romani… - International Journal of …, 2020 - mdpi.com
Dysregulated inflammasome activation and interleukin (IL)-1β production are associated
with several inflammatory disorders. Three different routes can lead to inflammasome …

CORM-3 ameliorates neurodegeneration in the amygdala and improves depression-and anxiety-like behavior in a rat model of combined traumatic brain injury and …

Y Li, LM Zhang, DX Zhang, WC Zheng, Y Bai… - Neurochemistry …, 2020 - Elsevier
Objective Emotional disturbances characterized by depression and anxiety among survivors
of traumatic brain injury (TBI) impact the quality of life severely. Currently, there is a lack of …

[HTML][HTML] The role of serine/threonine protein kinases in cardiovascular disease and potential therapeutic methods

Y Wu, Y Zou, C Song, K Cao, K Cai, S Chen… - Biomedicine & …, 2024 - Elsevier
Protein phosphorylation is an important link in a variety of signaling pathways, and most of
the important life processes in cells involve protein phosphorylation. Based on the amino …

Advances in the Protective Mechanism of NO, H2S, and H2 in Myocardial Ischemic Injury

W Wang, T Ge, X Chen, Y Mao, Y Zhu - Frontiers in Cardiovascular …, 2020 - frontiersin.org
Myocardial ischemic injury is among the top 10 leading causes of death from cardiovascular
diseases worldwide. Myocardial ischemia is caused mainly by coronary artery occlusion or …

Downregulation of miR-214 promotes dilated Cardiomyopathy Progression through PDE5A-Mediated cGMP regulation

J Yan, X Wang, P Cao, Q Li, H Wu - Scientific Reports, 2024 - nature.com
Dilated cardiomyopathy (DCM) is a myocardial disorder resulting in a substantial decline in
cardiac function and potentially leading to heart failure. This research combines …

[HTML][HTML] Xanthine derivative KMUP-1 ameliorates retinopathy

JL Yeh, CH Kuo, PW Shih, JH Hsu, I Peng… - Biomedicine & …, 2023 - Elsevier
Retinal neovascularization (RNV) and cell apoptosis observed in retinopathy are the most
common cause of vision loss worldwide. Increasing vascular endothelial growth factor …