Mechanisms of lncRNA biogenesis as revealed by nascent transcriptomics
Mammalian genomes express two principal gene categories through RNA polymerase II-
mediated transcription: protein-coding transcription units and non-coding RNA transcription …
mediated transcription: protein-coding transcription units and non-coding RNA transcription …
[HTML][HTML] Properties and behavior of carbon nanomaterials when interfacing neuronal cells: How far have we come?
In the last two decades, an increasing amount of studies have investigated the use of
components based on carbon-(nano) materials in the engineering of neural interfaces, to …
components based on carbon-(nano) materials in the engineering of neural interfaces, to …
TERRA and RAD51AP1 promote alternative lengthening of telomeres through an R-to D-loop switch
Alternative lengthening of telomeres (ALT), a telomerase-independent process maintaining
telomeres, is mediated by break-induced replication (BIR). RAD52 promotes ALT by …
telomeres, is mediated by break-induced replication (BIR). RAD52 promotes ALT by …
Damage-induced lncRNAs control the DNA damage response through interaction with DDRNAs at individual double-strand breaks
The DNA damage response (DDR) preserves genomic integrity. Small non-coding RNAs
termed DDRNAs are generated at DNA double-strand breaks (DSBs) and are critical for …
termed DDRNAs are generated at DNA double-strand breaks (DSBs) and are critical for …
Transcript-RNA-templated DNA recombination and repair
Homologous recombination is a molecular process that has multiple important roles in DNA
metabolism, both for DNA repair and genetic variation in all forms of life. Generally …
metabolism, both for DNA repair and genetic variation in all forms of life. Generally …
RAD51AP1 regulates ALT-HDR through chromatin-directed homeostasis of TERRA
N Kaminski, AR Wondisford, Y Kwon, ML Lynskey… - Molecular cell, 2022 - cell.com
Alternative lengthening of telomeres (ALT) is a homology-directed repair (HDR) mechanism
of telomere elongation that controls proliferation in subsets of aggressive cancer. Recent …
of telomere elongation that controls proliferation in subsets of aggressive cancer. Recent …
Minimizing the damage: repair pathways keep mitochondrial DNA intact
Mitochondrial DNA (mtDNA) faces the universal challenges of genome maintenance: the
accurate replication, transmission and preservation of its integrity throughout the life of the …
accurate replication, transmission and preservation of its integrity throughout the life of the …
The democratization of gene editing: Insights from site-specific cleavage and double-strand break repair
M Jasin, JE Haber - DNA repair, 2016 - Elsevier
DNA double-strand breaks (DSBs) are dangerous lesions that if not properly repaired can
lead to genomic change or cell death. Organisms have developed several pathways and …
lead to genomic change or cell death. Organisms have developed several pathways and …
Immediate-early, early, and late responses to DNA double stranded breaks
SR Kieffer, NF Lowndes - Frontiers in Genetics, 2022 - frontiersin.org
Loss or rearrangement of genetic information can result from incorrect responses to DNA
double strand breaks (DSBs). The cellular responses to DSBs encompass a range of highly …
double strand breaks (DSBs). The cellular responses to DSBs encompass a range of highly …
Precise gene replacement in rice by RNA transcript-templated homologous recombination
One of the main obstacles to gene replacement in plants is efficient delivery of a donor
repair template (DRT) into the nucleus for homology-directed DNA repair (HDR) of double …
repair template (DRT) into the nucleus for homology-directed DNA repair (HDR) of double …