The widespread regulation of microRNA biogenesis, function and decay

J Krol, I Loedige, W Filipowicz - Nature reviews genetics, 2010 - nature.com
MicroRNAs (miRNAs) are a large family of post-transcriptional regulators of gene expression
that are∼ 21 nucleotides in length and control many developmental and cellular processes …

[HTML][HTML] Origins and mechanisms of miRNAs and siRNAs

RW Carthew, EJ Sontheimer - Cell, 2009 - cell.com
Over the last decade,∼ 20–30 nucleotide RNA molecules have emerged as critical
regulators in the expression and function of eukaryotic genomes. Two primary categories of …

Many roads to maturity: microRNA biogenesis pathways and their regulation

J Winter, S Jung, S Keller, RI Gregory… - Nature cell biology, 2009 - nature.com
MicroRNAs are important regulators of gene expression that control both physiological and
pathological processes such as development and cancer. Although their mode of action has …

A-to-I editing of coding and non-coding RNAs by ADARs

K Nishikura - Nature reviews Molecular cell biology, 2016 - nature.com
Adenosine deaminases acting on RNA (ADARs) convert adenosine to inosine in double-
stranded RNA. This A-to-I editing occurs not only in protein-coding regions of mRNAs, but …

MiRNA biogenesis and regulation of diseases: an overview

A Vishnoi, S Rani - MicroRNA profiling: Methods and protocols, 2017 - Springer
MicroRNAs (miRNAs) are small RNA molecules, with their role in gene silencing and
translational repression by binding to target mRNAs. Since it was discovered in 1993 …

Molecular mechanisms of RNA interference

RC Wilson, JA Doudna - Annual review of biophysics, 2013 - annualreviews.org
Small RNA molecules regulate eukaryotic gene expression during development and in
response to stresses including viral infection. Specialized ribonucleases and RNA-binding …

Innate immunity to virus infection

O Takeuchi, S Akira - Immunological reviews, 2009 - Wiley Online Library
The innate immune system is essential for the initial detection of invading viruses and
subsequent activation of adaptive immunity. Three classes of receptors, designated retinoic …

Structure of the human DICER–pre-miRNA complex in a dicing state

YY Lee, H Lee, H Kim, VN Kim, SH Roh - Nature, 2023 - nature.com
Dicer has a key role in small RNA biogenesis, processing double-stranded RNAs
(dsRNAs),. Human DICER (hDICER, also known as DICER1) is specialized for cleaving …

miRNA biogenesis and regulation of diseases: an updated overview

A Vishnoi, S Rani - MicroRNA Profiling: Methods and Protocols, 2022 - Springer
MicroRNAs (miRNAs) are small RNA molecules, with their role in gene silencing and
translational repression by binding to the target mRNAs. Since it was discovered in 1993 …

DICER1: mutations, microRNAs and mechanisms

WD Foulkes, JR Priest, TF Duchaine - Nature Reviews Cancer, 2014 - nature.com
Dicer is central to microRNA-mediated silencing and several other RNA interference
phenomena that are profoundly embedded in cancer gene networks. Most recently, both …