All transcription factors are equal, but some are more equal than others. In the 25 yr since
the gene encoding the microphthalmia-associated transcription factor (MITF) was first …

Post-translational protein modification by small ubiquitin-like modifier (SUMO), termed
sumoylation, is an important mechanism in cellular responses to stress and one that …

Most genetic susceptibility to cutaneous melanoma remains to be discovered. Meta-analysis
genome-wide association study (GWAS) of 36,760 cases of melanoma (67% newly …

Kidney cancer is not a single disease but represents several distinct types of cancer that
have defining histologies and genetic alterations and that follow different clinical courses …

Increased expression of the Microphthalmia-associated transcription factor (MITF)
contributes to melanoma progression and resistance to BRAF pathway inhibition. Here we …

Certain transcription factors have vital roles in lineage development, including specification
of cell types and control of differentiation. Microphthalmia-associated transcription factor …

Activating mutations in BRAF are the most common genetic alterations in melanoma.
Inhibition of BRAF by small molecules leads to cell-cycle arrest and apoptosis. We show …

In the past decade, major advances have been made in the understanding of melanoma.
New predisposition genes have been reported and key somatic events, such as BRAF …

Cancer cells reprogram their metabolism using different strategies to meet energy and
anabolic demands to maintain growth and survival. Understanding the molecular and …

Melanoma, the deadliest form of skin cancer, is an aggressive disease that is rising in
incidence. Although melanoma is a historically treatment-resistant malignancy, in recent …