The vascular endothelium, a monolayer of endothelial cells (EC), constitutes the inner
cellular lining of arteries, veins and capillaries and therefore is in direct contact with the …

Primary cilia project in a single copy from the surface of most vertebrate cell types; they
detect and transmit extracellular cues to regulate diverse cellular processes during …

Blood flow produces mechanical frictional forces, parallel to the blood flow exerted on the
endothelial wall of the vessel, the so-called wall shear stress (WSS). WSS sensing is …

Endothelial cells (ECs) lining all blood vessels are subjected to large mechanical stresses
that regulate their structure and function in health and disease. Here, we review EC …

The primary cilium, which was first so named by Sergei Sorokin (Sorokin, 1968), is a solitary
organelle that emanates from the cell surface of most mammalian cell types during growth …

Located in the innermost layer of the vasculature and directly interacting with blood flow,
endothelium integrates various biochemical and biomechanical signals to maintain barrier …

The endothelial glycocalyx (EG), which covers the apical surface of the endothelial cells and
floats into the lumen of the vessels, is a key player in vascular integrity and cardiovascular …

Endothelial cells are covered with a polysaccharide rich layer more than 400 nm thick,
mechanical properties of which limit access of circulating plasma components to endothelial …

Stem cells interpret signals from their microenvironment while simultaneously modifying the
niche through secreting factors and exerting mechanical forces. Many soluble stem cell cues …

Endothelial cells (ECs) lining blood vessel walls respond to shear stress, a fluid mechanical
force generated by flowing blood, and the EC responses play an important role in the …