Understanding microRNA-mediated gene regulatory networks through mathematical modelling
The discovery of microRNAs (miRNAs) has added a new player to the regulation of gene
expression. With the increasing number of molecular species involved in gene regulatory …
expression. With the increasing number of molecular species involved in gene regulatory …
U7 snRNA, a small RNA with a big impact in gene therapy
The uridine-rich 7 (U7) small nuclear RNA (snRNA) is a component of a small nuclear
ribonucleoprotein (snRNP) complex. U7 snRNA naturally contains an antisense sequence …
ribonucleoprotein (snRNP) complex. U7 snRNA naturally contains an antisense sequence …
A synthetic circuit for buffering gene dosage variation between individual mammalian cells
Precise control of gene expression is critical for biological research and biotechnology.
However, transient plasmid transfections in mammalian cells produce a wide distribution of …
However, transient plasmid transfections in mammalian cells produce a wide distribution of …
Mathematical modeling of combinatorial regulation suggests that apparent positive regulation of targets by miRNA could be an artifact resulting from competition for …
D Nyayanit, CJ Gadgil - Rna, 2015 - rnajournal.cshlp.org
MicroRNAs bind to and regulate the abundance and activity of target messenger RNA
through sequestration, enhanced degradation, and suppression of translation. Although …
through sequestration, enhanced degradation, and suppression of translation. Although …
Demyelinating neuropathy in a patient treated with revusiran for transthyretin (Thr60Ala) amyloidosis
Transthyretin amyloidosis patients develop length-dependent peripheral neuropathy,
autonomic dysfunction, and restrictive cardiomyopathy associated with deposition of amyloid …
autonomic dysfunction, and restrictive cardiomyopathy associated with deposition of amyloid …
Connecting the molecular function of microRNAs to cell differentiation dynamics
R Posner, R Laubenbacher - Journal of the Royal …, 2019 - royalsocietypublishing.org
MicroRNAs form a class of short, non-coding RNA molecules which are essential for proper
development in tissue-based plants and animals. To help explain their role in gene …
development in tissue-based plants and animals. To help explain their role in gene …
Theoretical studies on sRNA-mediated regulation in bacteria
XX Chang, LF Xu, HL Shi - Chinese Physics B, 2015 - iopscience.iop.org
Small RNA (sRNA)-mediated post-transcriptional regulation differs from protein-mediated
regulation. Through base-pairing, sRNA can regulate the target mRNA in a catalytic or …
regulation. Through base-pairing, sRNA can regulate the target mRNA in a catalytic or …
The Role of CAF-1 in Epigenetic Conversions at the Telomeres of Saccharomyces cerevisiae and its Control by Protein Kinases
DCB Jeffery - 2014 - atrium.lib.uoguelph.ca
Epigenetics is the study of heritable changes in gene expression that are not caused by
changes in the DNA sequence. The expression profile of a given cell is regulated by the …
changes in the DNA sequence. The expression profile of a given cell is regulated by the …
[BOOK][B] The Role of microRNA-Mediated Gene Regulation in Development
R Posner - 2021 - search.proquest.com
In the face of random perturbations in environment as well as genetic mutations, complex
organisms manage to maintain remarkably robust developmental stability. Despite …
organisms manage to maintain remarkably robust developmental stability. Despite …
Mathematical model for autoregulated miRNA biogenesis
DA Nyayanit, CJ Gadgil - arxiv preprint arxiv:2001.11641, 2020 - arxiv.org
MicroRNAs are small non-coding nucleotide sequences that regulate target protein
expression at post-transcriptional levels. Biogenesis of microRNA is a highly regulated multi …
expression at post-transcriptional levels. Biogenesis of microRNA is a highly regulated multi …