Proprotein convertase subtilisin/kexin type 9 (PCSK9) has evolved as a pivotal enzyme in
lipid metabolism and a revolutionary therapeutic target for hypercholesterolemia and its …

Sarcopenia, an age-associated decline in skeletal muscle mass coupled with functional
deterioration, may be exacerbated by obesity leading to higher disability, frailty, morbidity …

Accumulating evidence indicates that obesity is closely associated with an increased risk of
metabolic diseases such as insulin resistance, type 2 diabetes, dyslipidemia and …

Obesity is characterized by a state of chronic, low-grade inflammation. However, excessive
fatty acid release may worsen adipose tissue inflammation and contributes to insulin …

Chronic inflammatory state in obesity causes dysregulation of the endocrine and paracrine
actions of adipocyte-derived factors, which disrupt vascular homeostasis and contribute to …

Adipose tissue constitutes an extremely active endocrine organ with a network of signaling
pathways enabling the organism to adapt to a wide range of different metabolic challenges …

The immune system is responsible for defending an organism against the myriad of
microbial invaders it constantly confronts. It has become increasingly clear that the immune …

Chronic, low-grade inflammation of visceral adipose tissue, and systemically, is a critical link
between recent strikingly parallel rises in the incidence of obesity and type 2 diabetes …

Obesity is the hallmark of the metabolic syndrome and predisposes patients to the
development of major chronic metabolic diseases including type 2 diabetes mellitus …

The role of IL-6R/IL-6 axis in metabolic inflammation remains controversial. We determined
the changes in adipose tissue expression of IL-6R and IL-6 in obese, overweight, and lean …