Illuminating the landscape of host–pathogen interactions with the bacterium Listeria monocytogenes

P Cossart - Proceedings of the National Academy of Sciences, 2011 - pnas.org
Listeria monocytogenes has, in 25 y, become a model in infection biology. Through the
analysis of both its saprophytic life and infectious process, new concepts in microbiology …

Metabolic host responses to infection by intracellular bacterial pathogens

W Eisenreich, J Heesemann, T Rudel… - Frontiers in cellular and …, 2013 - frontiersin.org
The interaction of bacterial pathogens with mammalian hosts leads to a variety of
physiological responses of the interacting partners aimed at an adaptation to the new …

Tyrosine phosphorylation and bacterial virulence

SE Whitmore, RJ Lamont - International journal of oral science, 2012 - nature.com
Protein phosphorylation on tyrosine has emerged as a key device in the control of numerous
cellular functions in bacteria. In this article, we review the structure and function of bacterial …

Mycobacterium tuberculosis-secreted phosphatases: from pathogenesis to targets for TB drug development

D Wong, JD Chao, Y Av-Gay - Trends in microbiology, 2013 - cell.com
Mycobacterium tuberculosis (Mtb) infects human alveolar macrophages and relies on the
inhibition of phagosome acidification and maturation. This is, in part, dependent on the …

Function of macrophage and parasite phosphatases in leishmaniasis

D Soulat, C Bogdan - Frontiers in immunology, 2017 - frontiersin.org
The kinetoplastid protozoan parasites belonging to the genus Leishmania are the causative
agents of different clinical forms of leishmaniasis, a vector-borne infectious disease with …

Protein phosphatases of pathogenic bacteria: role in physiology and virulence

A Sajid, G Arora, A Singhal, VC Kalia… - Annual review of …, 2015 - annualreviews.org
The role of protein phosphatases in pathogenic bacteria has been studied extensively over
the last two decades. Ser/Thr and Tyr phosphatases are associated with growth and …

Structure-Based Design of MptpB Inhibitors That Reduce Multidrug-Resistant Mycobacterium tuberculosis Survival and Infection Burden in Vivo

CF Vickers, APG Silva, A Chakraborty… - Journal of medicinal …, 2018 - ACS Publications
Mycobacterium tuberculosis protein-tyrosine-phosphatase B (MptpB) is a secreted virulence
factor that subverts antimicrobial activity in the host. We report here the structure-based …

Microbial community function in the bleaching disease of the marine macroalgae Delisea pulchra

E Zozaya‐Valdés, AJ Roth‐Schulze… - Environmental …, 2017 - Wiley Online Library
Disease is increasingly viewed as a major factor impacting the health of both natural and
cultured populations of marine organisms, including macroalgae. The red macroalga …

Analysis of the serine/threonine/tyrosine phosphoproteome of the pathogenic bacterium Listeria monocytogenes reveals phosphorylated proteins related to virulence

SK Misra, E Milohanic, F Aké, I Mijakovic… - …, 2011 - Wiley Online Library
Phosphorylation is the most common and widely studied post‐translational protein
modification in bacteria. It plays an important role in all kinds of cellular processes and …

CD83 orchestrates immunity toward self and non-self in dendritic cells

AB Wild, L Krzyzak, K Peckert, L Stich, C Kuhnt… - JCI …, 2019 - pmc.ncbi.nlm.nih.gov
Dendritic cells (DCs) are crucial to balance protective immunity and autoimmune
inflammatory processes. Expression of CD83 is a well-established marker for mature DCs …