Recent studies have brought forward the critical role of emergent properties in sha**
microbial communities and the ecosystems of which they are a part. Emergent properties …

Microbial carbon use efficiency (CUE) affects the fate and storage of carbon in terrestrial
ecosystems, but its global importance remains uncertain. Accurately modeling and …

Resource allocation affects the structure of microbiomes, including those associated with
living hosts. Understanding the degree to which this dependency determines interspecies …

Industrialization and other anthropogenic human activities pose significant environmental
risks. As a result of the hazardous pollution, numerous living organisms may suffer from …

Communities of microorganisms (microbiota) are present in all habitats on Earth and are
relevant for agriculture, health, and climate. Deciphering the mechanisms that determine …

Epistatic interactions between mutations add substantial complexity to adaptive landscapes
and are often thought of as detrimental to our ability to predict evolution. Yet, patterns of …

Metabolism is the complex network of chemical reactions occurring within every cell and
organism, maintaining life, mediating ecosystem processes and affecting Earth's climate …

Constraint-based modeling (CBM) has evolved as the core systems biology tool to map the
interrelations between genotype, phenotype, and external environment. The recent …

Highlights•Analysis and designing of microbiomes have become a new paradigm in
microbiology.•Understanding and rational engineering of microbiomes require model-based …

Computational modeling of microbial communities using GEnome-scale Models (GEMs) of
metabolism is a new frontier in systems biology. Here, we discuss recent developments in …