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miRNAS in cardiovascular diseases: potential biomarkers, therapeutic targets and challenges
S Zhou, J **, J Wang, Z Zhang, JH Freedman… - Acta Pharmacologica …, 2018 - nature.com
Cardiovascular diseases (CVD) are the leading cause of morbidity and mortality in the
world. Although considerable progress has been made in the diagnosis, treatment and …
world. Although considerable progress has been made in the diagnosis, treatment and …
Pathophysiology of cardiac hypertrophy and heart failure: signaling pathways and novel therapeutic targets
The onset of heart failure is typically preceded by cardiac hypertrophy, a response of the
heart to increased workload, a cardiac insult such as a heart attack or genetic mutation …
heart to increased workload, a cardiac insult such as a heart attack or genetic mutation …
Therapeutic targeting of non-coding RNAs in cancer
The majority of the human genome encodes RNAs that do not code for proteins. These non-
coding RNAs (ncRNAs) affect normal expression of the genes, including oncogenes and …
coding RNAs (ncRNAs) affect normal expression of the genes, including oncogenes and …
MicroRNA-34a: the bad guy in age-related vascular diseases
A Raucci, F Macrì, S Castiglione, I Badi… - Cellular and Molecular …, 2021 - Springer
The age-related vasculature alteration is the prominent risk factor for vascular diseases
(VD), namely, atherosclerosis, abdominal aortic aneurysm, vascular calcification (VC) and …
(VD), namely, atherosclerosis, abdominal aortic aneurysm, vascular calcification (VC) and …
MicroRNAs in myocardial infarction
MicroRNAs (miRNAs) are small noncoding RNAs that block translation or induce
degradation of mRNA and thereby control patterns of gene expression. Acute myocardial …
degradation of mRNA and thereby control patterns of gene expression. Acute myocardial …
miRNA therapeutics: a new class of drugs with potential therapeutic applications in the heart
miRNAs are small non-coding RNAs (ncRNAs), which regulate gene expression. Here, the
authors describe the contribution of miRNAs to cardiac biology and disease. They discuss …
authors describe the contribution of miRNAs to cardiac biology and disease. They discuss …
Clinical development of TargomiRs, a miRNA mimic-based treatment for patients with recurrent thoracic cancer
miRNAs are responsible for post-transcriptional control of gene expression, and are
frequently downregulated in cancer. It has become well established that restoring miRNA …
frequently downregulated in cancer. It has become well established that restoring miRNA …
MicroRNA-34a plays a key role in cardiac repair and regeneration following myocardial infarction
Rationale: In response to injury, the rodent heart is capable of virtually full regeneration via
cardiomyocyte proliferation early in life. This regenerative capacity, however, is diminished …
cardiomyocyte proliferation early in life. This regenerative capacity, however, is diminished …
Understanding key mechanisms of exercise-induced cardiac protection to mitigate disease: current knowledge and emerging concepts
The benefits of exercise on the heart are well recognized, and clinical studies have
demonstrated that exercise is an intervention that can improve cardiac function in heart …
demonstrated that exercise is an intervention that can improve cardiac function in heart …
Targeting the microRNA-34a as a novel therapeutic strategy for cardiovascular diseases
CC Hua, XM Liu, LR Liang, LF Wang… - Frontiers in …, 2022 - frontiersin.org
Cardiovascular diseases (CVDs) are still the main cause of morbidity and mortality
worldwide and include a group of disorders varying from vasculature, myocardium …
worldwide and include a group of disorders varying from vasculature, myocardium …