miRNAS in cardiovascular diseases: potential biomarkers, therapeutic targets and challenges

S Zhou, J **, J Wang, Z Zhang, JH Freedman… - Acta Pharmacologica …, 2018 - nature.com
Cardiovascular diseases (CVD) are the leading cause of morbidity and mortality in the
world. Although considerable progress has been made in the diagnosis, treatment and …

Pathophysiology of cardiac hypertrophy and heart failure: signaling pathways and novel therapeutic targets

YK Tham, BC Bernardo, JYY Ooi, KL Weeks… - Archives of …, 2015 - Springer
The onset of heart failure is typically preceded by cardiac hypertrophy, a response of the
heart to increased workload, a cardiac insult such as a heart attack or genetic mutation …

Therapeutic targeting of non-coding RNAs in cancer

O Slaby, R Laga, O Sedlacek - Biochemical journal, 2017 - portlandpress.com
The majority of the human genome encodes RNAs that do not code for proteins. These non-
coding RNAs (ncRNAs) affect normal expression of the genes, including oncogenes and …

MicroRNA-34a: the bad guy in age-related vascular diseases

A Raucci, F Macrì, S Castiglione, I Badi… - Cellular and Molecular …, 2021 - Springer
The age-related vasculature alteration is the prominent risk factor for vascular diseases
(VD), namely, atherosclerosis, abdominal aortic aneurysm, vascular calcification (VC) and …

MicroRNAs in myocardial infarction

RA Boon, S Dimmeler - Nature Reviews Cardiology, 2015 - nature.com
MicroRNAs (miRNAs) are small noncoding RNAs that block translation or induce
degradation of mRNA and thereby control patterns of gene expression. Acute myocardial …

miRNA therapeutics: a new class of drugs with potential therapeutic applications in the heart

BC Bernardo, JYY Ooi, RCY Lin… - Future medicinal …, 2015 - Taylor & Francis
miRNAs are small non-coding RNAs (ncRNAs), which regulate gene expression. Here, the
authors describe the contribution of miRNAs to cardiac biology and disease. They discuss …

Clinical development of TargomiRs, a miRNA mimic-based treatment for patients with recurrent thoracic cancer

G Reid, SC Kao, N Pavlakis, H Brahmbhatt… - …, 2016 - Taylor & Francis
miRNAs are responsible for post-transcriptional control of gene expression, and are
frequently downregulated in cancer. It has become well established that restoring miRNA …

MicroRNA-34a plays a key role in cardiac repair and regeneration following myocardial infarction

Y Yang, HW Cheng, Y Qiu, D Dupee… - Circulation …, 2015 - ahajournals.org
Rationale: In response to injury, the rodent heart is capable of virtually full regeneration via
cardiomyocyte proliferation early in life. This regenerative capacity, however, is diminished …

Understanding key mechanisms of exercise-induced cardiac protection to mitigate disease: current knowledge and emerging concepts

BC Bernardo, JYY Ooi, KL Weeks… - Physiological …, 2018 - journals.physiology.org
The benefits of exercise on the heart are well recognized, and clinical studies have
demonstrated that exercise is an intervention that can improve cardiac function in heart …

Targeting the microRNA-34a as a novel therapeutic strategy for cardiovascular diseases

CC Hua, XM Liu, LR Liang, LF Wang… - Frontiers in …, 2022 - frontiersin.org
Cardiovascular diseases (CVDs) are still the main cause of morbidity and mortality
worldwide and include a group of disorders varying from vasculature, myocardium …