Apoptotic bodies: bioactive treasure left behind by the dying cells with robust diagnostic and therapeutic application potentials

L Yu, G Zhu, Z Zhang, Y Yu, L Zeng, Z Xu… - Journal of …, 2023 - Springer
Apoptosis, a form of programmed cell death, is essential for growth and tissue homeostasis.
Apoptotic bodies (ApoBDs) are a form of extracellular vesicles (EVs) released by dying cells …

Apoptotic bodies for advanced drug delivery and therapy

M Zhou, YJ Li, YC Tang, XY Hao, WJ Xu… - Journal of Controlled …, 2022 - Elsevier
Extracellular vesicles (EVs) have emerged as promising candidates for multiple biomedical
applications. Major types of EVs include exosomes, microvesicles, and apoptotic bodies …

Riding apoptotic bodies for cell–cell transmission by African swine fever virus

P Gao, L Zhou, J Wu, W Weng, H Wang, M Ye… - Proceedings of the …, 2023 - pnas.org
African swine fever virus (ASFV), a devastating pathogen to the worldwide swine industry,
mainly targets macrophage/monocyte lineage, but how the virus enters host cells has …

Advances in biological functions and applications of apoptotic vesicles

X Zou, Q Lei, X Luo, J Yin, S Chen, C Hao… - Cell Communication and …, 2023 - Springer
Background Apoptotic vesicles are extracellular vesicles generated by apoptotic cells that
were previously regarded as containing waste or harmful substances but are now thought to …

Translating extracellular vesicle packaging into therapeutic applications

DC Ozkocak, TK Phan, IKH Poon - Frontiers in immunology, 2022 - frontiersin.org
Extracellular vesicles (EVs) are membrane-bound particles released by cells in various
(patho) physiological conditions. EVs can transfer effector molecules and elicit potent …

Unleashing the therapeutic potential of apoptotic bodies

TK Phan, DC Ozkocak, IKH Poon - Biochemical society …, 2020 - portlandpress.com
Extracellular vesicles (EVs), membrane-bound vesicles that are naturally released by cells,
have emerged as new therapeutic opportunities. EVs, particularly exosomes and …

Apoptotic Vesicles of MSCs: The Natural Therapeutic Agents and Bio‐Vehicles for Targeting Drug Delivery

R Lin, T Zhang, J Gao - Small, 2023 - Wiley Online Library
Mesenchymal stem cell (MSC)‐based therapies are increasingly recognized as promising
cellular therapeutics and show the ability to treat various diseases. However, the underlying …

Mesenchymal stem cells-derived apoptotic extracellular vesicles (ApoEVs): mechanism and application in tissue regeneration

Y Zhu, X Chen, Y Liao - Stem Cells, 2023 - academic.oup.com
Mesenchymal stem cells (MSCs) are commonly used as a source for cellular therapy owing
to their strong immunosuppressive and regenerative effects. However, MSCs undergo …

Diversity of intercellular communication modes: A cancer biology perspective

T Ebrahim, AS Ebrahim, M Kandouz - Cells, 2024 - mdpi.com
From the moment a cell is on the path to malignant transformation, its interaction with other
cells from the microenvironment becomes altered. The flow of molecular information is at the …

Exploring the metabolic differences between cisplatin-and uv light-induced apoptotic bodies in HK-2 Cells by an untargeted metabolomics approach

S Bernardo-Bermejo, E Sánchez-López… - International Journal of …, 2023 - mdpi.com
Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the
apoptosis and perform a relevant role in the pathogenesis of different diseases. Recently, it …