The glutamate and dopamine hypotheses are leading theories of the pathoaetiology of
schizophrenia. Both were initially based on indirect evidence from pharmacological studies …

Ethnic minority groups across the world face a complex set of adverse social and
psychological challenges linked to their minority status, often involving racial discrimination …

Translating advances in neuroscience into benefits for patients with mental illness presents
enormous challenges because it involves both the most complex organ, the brain, and its …

We propose that schizophrenia involves a combination of decreased phasic dopamine
responses for relevant stimuli and increased spontaneous phasic dopamine release. Using …

The dopamine hypothesis of schizophrenia has been one of the most enduring ideas in
psychiatry. Initially, the emphasis was on a role of hyperdopaminergia in the etiology of …

While contemporary models of psychosis have proposed a number of putative psychological
mechanisms, how these impact on individuals to increase intensity of psychotic experiences …

Advances in cognitive neuroscience offer us new ways to understand the symptoms of
mental illness by uniting basic neurochemical and neurophysiological observations with the …

We discuss the importance of cognitive abnormalities in unipolar depression, drawing the
distinction between “hot”(emotion-laden) and “cold”(emotion-independent) cognition.“Cold” …

Over the last 2 decades, a large number of neurophysiological and neuroimaging studies of
patients with schizophrenia have furnished in vivo evidence for dysconnectivity, ie, abnormal …

A range of emotional and motivation impairments have long been clinically documented in
people with schizophrenia, and there has been a resurgence of interest in understanding …