Pseudomonas aeruginosa is a major opportunistic pathogen, causing a wide range of acute
and chronic infections. β-lactam antibiotics including penicillins, carbapenems …

Abstract Purpose of Review As the sixth most common nosocomial pathogen in the USA,
Pseudomonas aeruginosa poses a significant threat to patients within the healthcare …

Peptidoglycan (PG) is an essential macromolecular sacculus surrounding most bacteria. It is
assembled by the glycosyltransferase (GT) and transpeptidase (TP) activities of …

The focus of structural biology is shifting from the determination of static structures to the
investigation of dynamical aspects of macromolecular function. With time-resolved …

Penicillin-binding proteins (PBPs) are enzymes responsible for the polymerization of the
glycan strand and the cross-linking between glycan chains as well as the target proteins for …

Even with the emergence of antibiotic resistance, penicillin and the wider family of β-lactams
have remained the single most important family of antibiotics. The periplasmic/extra …

In Escherichia coli, penicillin-binding protein 3 (PBP3), also known as FtsI, is a central
component of the divisome, catalyzing cross-linking of the cell wall peptidoglycan during cell …

Background Schiff base compounds have extensive applications in various fields such as
analytical, inorganic, organic, and biological fields. They have excellent pharmacology …

Multidrug-resistant (MDR) pathogens pose a significant public health threat. A major
mechanism of resistance expressed by MDR pathogens is β-lactamase-mediated …

The effectiveness of β-lactam antibiotics is increasingly compromised by β-lactamases.
Boron-containing inhibitors are potent serine-β-lactamase inhibitors, but the interactions of …