The liver can precisely regulate its growth and mass. Surgical resection of hepatic lobes or
hepatocyte loss caused by viral or chemical injury triggers hepatocyte replication while …

Low power laser irradiation (LPLI) promotes proliferation of multiple cells, which (especially
red and near infrared light) is mainly through the activation of mitochondrial respiratory chain …

Among numerous established human hepatoma cell lines, none has been shown
susceptible to hepatitis B virus (HBV) infection. We describe here a cell line, called HepaRG …

In vitro liver preparations are increasingly used for the study of hepatotoxicity of chemicals.
In recent years their actual advantages and limitations have been better defined. The cell …

Primary hepatocytes and their cultures are a simple but versatile, well-controlled, and
relatively easy to handle in vitro system that is well-accepted for investigating xenobiotic …

In vitro hepatocyte models represent very useful systems in both fundamental research and
various application areas. Primary hepatocytes appear as the closest model for the liver in …

Uncontrolled cell division is a defining characteristic of cancer cells. Cyclin-dependent
kinases (Cdks) are critical regulators of cell cycle progression. Deregulated Cdk activities as …

After two-thirds hepatectomy, normally quiescent liver cells are stimulated to reenter the cell
cycle and proliferate to restore the original liver mass. The level of bZIP transcription factor …

E-type cyclins (cyclin E1 and cyclin E2) are expressed during the late G1 phase of the cell
cycle until the end of the S-phase. The activity of cyclin E is limiting for the passage of cells …

Liver regeneration is an important and necessary process that the liver depends on for
recovery from injury. The regeneration process consists of a complex network of cells and …